4-(4-羟基苯氧基)苯甲酸合成路线 （共 7 条）
反应条件
hydrogen; 10 palladium on activated carbon in ethyl acetate P=2068.65 Torr; 18 h;
参考文献
Reiter, Lawrence Alan; Freeman-Cook, Kevin Daniel
Patent: US2004/6057 A1, 2004 ;
Location in patent: Page/Page column 30 ;
反应条件
hydrogen bromide; tetra-(n-butyl)-phosphonium bromide T=100°C; 9 h;
参考文献
Hwang; Park
Synthetic Communications, 1993 , vol. 23, # 20 p. 2845 - 2849
反应条件
1: potassium hydroxide / N,N-dimethyl-formamide / 0.33 h / 175 °C / |Sealed tube 2: Jone's reagent / acetone 3: hydrogen bromide; acetic acid / 12 h / |Reflux View Scheme
参考文献
Kormos, Chad M.; Jin, Chunyang; Cueva, Juan Pablo; Runyon, Scott P.; Thomas, James B.; Brieaddy, Lawrence E.; Mascarella, S. Wayne; Navarro, Hernan A.; Gilmour, Brian P.; Carroll, F. Ivy
Journal of Medicinal Chemistry, 2013 , vol. 56, # 11 p. 4551 - 4567
反应条件
1: potassium hydroxide / N,N-dimethyl-formamide / 0.33 h / 175 °C / |Sealed tube 2: Jone's reagent / acetone 3: hydrogen bromide; acetic acid / 12 h / |Reflux View Scheme
参考文献
Kormos, Chad M.; Jin, Chunyang; Cueva, Juan Pablo; Runyon, Scott P.; Thomas, James B.; Brieaddy, Lawrence E.; Mascarella, S. Wayne; Navarro, Hernan A.; Gilmour, Brian P.; Carroll, F. Ivy
Journal of Medicinal Chemistry, 2013 , vol. 56, # 11 p. 4551 - 4567
反应条件
1: Jone's reagent / acetone 2: hydrogen bromide; acetic acid / 12 h / |Reflux View Scheme
参考文献
Kormos, Chad M.; Jin, Chunyang; Cueva, Juan Pablo; Runyon, Scott P.; Thomas, James B.; Brieaddy, Lawrence E.; Mascarella, S. Wayne; Navarro, Hernan A.; Gilmour, Brian P.; Carroll, F. Ivy
Journal of Medicinal Chemistry, 2013 , vol. 56, # 11 p. 4551 - 4567
反应条件
1: potassium carbonate; copper-powder / 200 - 215 °C / Erwaermen des Reaktionsgemisches mit wss. Kalilauge 2: aqueous hydrobromic acid; acetic acid View Scheme
参考文献
Walker
Journal of the Chemical Society, 1942 , p. 347,352
反应条件
1: potassium carbonate; copper-powder / 200 - 215 °C / Erwaermen des Reaktionsgemisches mit wss. Kalilauge 2: aqueous hydrobromic acid; acetic acid View Scheme
参考文献
Walker
Journal of the Chemical Society, 1942 , p. 347,352
