反应条件
1.1: triethylamine / dichloromethane / 20 °C 2.1: lithium hydroxide hydrate; water / tetrahydrofuran; methanol / 16 h / 20 °C 3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C / |Inert atmosphere 3.2: 4 h / 0 - 20 °C / |Inert atmosphere 3.3: 16 h / 0 - 20 °C View Scheme
参考文献
ZALICUS PHARMACEUTICALS LTD.; PAJOUHESH, Hassan, A.; HOLLAND, Richard; ZHANG, Lingyun; PAJOUHESH, Hossein, O.; LAMONTAGNE, Jason; WHELAN, Brendan; SHORT, Glenn, F., III.; ROMERO, Donna, L.
Patent: WO2013/131018 A1, 2013 ;