5-(2-乙氧基苯基)-2,6-二氢-2-甲基-3-丙基-7H-吡唑并[4,3-d]嘧啶-7-酮合成路线 （共 9 条）
反应条件
1.1: methanol / 0 - 5 °C
1.2: 36 percent / H2SO4 / 85 - 90 °C
2.1: 78 percent / H2SO4; HNO3 / 90 - 95 °C
3.1: SOCl2
3.2: 86 percent / NH4OH; water / 3 h / 20 °C
4.1: HCl; SnCl2; water / 20 °C
4.2: 90 percent / NaOH; water
5.1: 30 percent / polyphosphoric acid / Heating
View Scheme
参考文献
El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059
参考文献
El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059
参考文献
El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059
反应条件
1.1: 78 percent / H2SO4; HNO3 / 90 - 95 °C
2.1: SOCl2
2.2: 86 percent / NH4OH; water / 3 h / 20 °C
3.1: HCl; SnCl2; water / 20 °C
3.2: 90 percent / NaOH; water
4.1: 30 percent / polyphosphoric acid / Heating
View Scheme
参考文献
El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059
反应条件
1.1: HCl; SnCl2; water / 20 °C
1.2: 90 percent / NaOH; water
2.1: 30 percent / polyphosphoric acid / Heating
View Scheme
参考文献
El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059
反应条件
1.1: SOCl2
1.2: 86 percent / NH4OH; water / 3 h / 20 °C
2.1: HCl; SnCl2; water / 20 °C
2.2: 90 percent / NaOH; water
3.1: 30 percent / polyphosphoric acid / Heating
View Scheme
参考文献
El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059
反应条件
1.1: SOCl2 / 3 h / Heating
1.2: 88 percent / triethylamine; 4-(dimethylamino)pyridine / benzene / 3 h / Heating
2.1: 34 percent / polyphosphoric acid / Heating
View Scheme
参考文献
El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059
反应条件
1.1: SOCl2 / 3 h / Heating
1.2: 88 percent / triethylamine; 4-(dimethylamino)pyridine / benzene / 3 h / Heating
2.1: 34 percent / polyphosphoric acid / Heating
View Scheme
参考文献
El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059
反应条件
chlorosulfonic acid
T=65 - 70°C; 1 h;
参考文献
El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059
