1: cycloheptanone With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=-78°C;
2: With titanium(IV) isopropylate in tetrahydrofuran; hexane
T=-78°C;
3: perfluoromethyl iodide With triethyl borane in tetrahydrofuran; hexane
T=-78°C;
1: cycloheptanone With sodium hydride in N,N-dimethyl-formamide; mineral oil
T=25 - 40°C;
2: 2-(chloromethyl)-3,5-dioxahex-1-ene in N,N-dimethyl-formamide; mineral oil
T=120°C;
参考文献
IRONWOOD PHARMACEUTICALS, INC.; JIA, James; MERMERIAN, Ara; KIM, Charles; LUNDRIGAN, Regina; MOORE, Joel
Patent: WO2010/39982 A1, 2010 ;
Location in patent: Page/Page column 113-114 ;
WO 2010/039982 A1
