E.R. Squibb and Sons, Inc.
Patent: EP253179 A2, 1988 ;
EP 0253179 A2
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E.R. Squibb and Sons, Inc.
Patent: EP253179 B1, 1991 ;
1: conc. H2SO4 / Heating 2: pyridinium chlorochromate (PCC), sodium acetate / CH2Cl2 / 1.5 h / Ambient temperature 4: Na(Hg), MeOH / tetrahydrofuran / 8 h / -20 °C 5: aq. KOH / ethanol / 1 h / Heating 6: thionyl chloride / 1.) RT, 18 h, 2.) 100 deg C, 30 min 7: diethyl ether / 72 h / Ambient temperature View Scheme
参考文献
Gannett, Peter M.; Nagel, Donald L.; Reilly, Pam J.; Lawson, Terence; Sharpe, Jody; Toth, Bela
Journal of Organic Chemistry, 1988 , vol. 53, # 5 p. 1064 - 1071
1: With anhydrous iron chloride in tetrachloroethane, 1,1,2,2- T=85°C; 24 h; Inert atmosphere; 2: With hydrogenchloride; water in tetrachloroethane, 1,1,2,2- Inert atmosphere;
