1-氯-3-甲基-2-丁烯合成路线 （共 287 条）
反应条件
1: 30 percent / n-butyllithium, N,N,N',N'-tetramethylethylenediamine / tetrahydrofuran / -20 °C 2: 83 percent / hydroperoxide, vanadyl acetylacetonate / CH2Cl2 / 0 °C 3: ethanol; H2O / 16 h / Heating 4: toluene / Heating 5: 92 percent / methanesulfonyl chloride, triethylamine / CH2Cl2 / 0 °C 6: diisobutylaluminum hydride / toluene / -15 °C View Scheme
参考文献
Chemistry Letters, , p. 1261 - 1262
反应条件
1: CH(CH2CH=CH2)(CO2Me)2 With sodium hydride in tetrahydrofuran T=0 - 20°C; Inert atmosphere; 2: 1-chloro-3-methyl-2-butene in tetrahydrofuran T=0 - 20°C; Inert atmosphere;
参考文献
Dzudza, Alma; Marks, Tobin J.
Chemistry - A European Journal, 2010 , vol. 16, # 11 p. 3403 - 3422
反应条件
potassium carbonate in acetonitrile T=40°C; 20 h; Inert atmosphere;
参考文献
Orchard, Alexandra; Schamerhorn, Gregory A.; Calitree, Brandon D.; Sawada, Geri A.; Loo, Tip W.; Claire Bartlett; Clarke, David M.; Detty, Michael R.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 14 p. 4290 - 4302
反应条件
1: palladium dichloride; potassium acetate / tetrahydrofuran / 12 h / 60 °C / |Inert atmosphere 2: potassium phosphate; C26H39P; bis(η3-allyl-μ-chloropalladium(II)) / acetonitrile; water / 12 h / 70 °C / |Inert atmosphere View Scheme
参考文献
Yang, Yang; Buchwald, Stephen L.
Journal of the American Chemical Society, 2013 , vol. 135, # 29 p. 10642 - 10645
反应条件
in N,N-dimethyl-formamide T=20°C; Inert atmosphere;
参考文献
Liu, Na; Wang, Hao-Yuan; Zhang, Wei; Jia, Zhi-Hong; Guzei, Ilia A.; Xu, Hua-Dong; Tang, Weiping
Chirality, 2013 , vol. 25, # 11 p. 805 - 809
反应条件
tris(dibenzylideneacetone)dipalladium(0) chloroform complex in neat (no solvent) stirred at room temp. under Ar for 6 h, ether added, treated with KF; ppt. fluorotributylstannane filtered off, ether layer sepd., dried (MgSO4), concd., chromd. (SiO2, hexane); elem. anal.;
参考文献
Nakano, Taichi; Ono, Kazuyoshi; Senda, Yoshiya; Migita, Toshihiko
Journal of Organometallic Chemistry, 2001 , vol. 619, # 1-2 p. 313 - 317
反应条件
1: 1-chloro-3-methyl-2-butene With iodine; magnesium in tetrahydrofuran T=20°C; RefluxInert atmosphere; 2: carbon dioxide in tetrahydrofuran Inert atmosphere;
参考文献
Organic Letters, , vol. 13, # 5 p. 1080 - 1082
反应条件
tetrahydrofuran; magnesium anschliessend mit Kohlendioxid;
参考文献
Journal of the American Chemical Society, , vol. 76, p. 5403
反应条件
und anschliessend Behandeln mit festem Kohlendioxid;
参考文献
Journal of the American Chemical Society, , vol. 76, p. 5403
反应条件
acetic anhydride; zinc oxide T=15°C; 0.5 h;
参考文献
Tetrahedron, , vol. 38, # 12 p. 1843 - 1846
