5-溴-2-羟基-3-甲氧基苯甲醛合成路线 （共 25 条）
反应条件
[BBIm]Br3 T=20°C; 0.0333333 h; Neat (no solvent); regioselective reaction;
参考文献
Borikar; Daniel
Journal of the Iranian Chemical Society, 2011 , vol. 8, # 2 p. 531 - 536
反应条件
bromine in tetrachloromethane 15 h; Ambient temperature;
参考文献
Natarajan, S.; Rajeswari, S.; Chandrasekaran, S.; Pai, B. R.; Shanmuganathan, Sp.; Rao, K. Usha
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 2 p. 95 - 97
反应条件
und Erwaermen des Reaktionsprodukts unter vermindertem Druck auf 100grad und beim Behandeln der erhaltenen Substanz mit Brom in Essigsaeure;
参考文献
Henry; Sharp
Journal of the Chemical Society, 1930 , p. 2279,2287
反应条件
1.1: NaBH4 / methanol / 20 °C 2.1: aq. HBr / acetonitrile / Heating 3.1: Et3N / toluene / Heating 4.1: n-BuLi / tetrahydrofuran; hexane / -90 °C 4.2: tetrahydrofuran; hexane / 20 °C View Scheme
参考文献
Hagihara, Koji; Kashima, Hajime; Iida, Kyoichiro; Enokizono, Junichi; Uchida, Shin-ichi; Nonaka, Hiromi; Kurokawa, Masako; Shimada, Junichi
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 6 p. 1616 - 1621
反应条件
1: 93 percent / K2CO3 / butan-2-one / 2 h / 80 °C 2: 72 percent / KMnO4; K2HPO4*3H2O / 2-methyl-propan-2-ol; H2O / 0.5 h 3: SOCl2; DMF / toluene / 2 h / 80 °C 4: 3.18 g / CH2Cl2 / 20 °C View Scheme
参考文献
De Paulis; Smith
Synthetic Communications, 1991 , vol. 21, # 8-9 p. 1091 - 1095
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 3 h;
参考文献
Ocheskey, Joseph A.; Harpstrite, Scott E.; Oksman, Anna; Goldberg, Daniel E.; Sharma, Vijay
Chemical Communications, 2005 , # 12 p. 1622 - 1624
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2004/41275 A1, 2004 ;
Location in patent: Page/Page column 27 ;
WO 2004/041275 A1
反应条件
potassium hydroxide; hydrazine hydrate 1) reflux, 5 h, 2) reflux, 5 h; Multistep reaction. Title compound not separated from byproducts;
参考文献
Daukshas, V. K.; Martinkus, R. S.; Kuleshyus, V. A.; Shtel'bene, V. P.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, p. 458 - 463
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 3 p. 522 - 528
反应条件
1: aq. H2O2, NaOH 2: aq. NaOH View Scheme
参考文献
Larsson,S.; Miksche,G.E.
Acta Chemica Scandinavica (1947-1973), 1972 , vol. 26, p. 2031 - 2038
反应条件
potassium hydroxide; hydrazine hydrate 1) reflux, 5 h, 2) reflux, 5 h; Multistep reaction. Title compound not separated from byproducts;
参考文献
Daukshas, V. K.; Martinkus, R. S.; Kuleshyus, V. A.; Shtel'bene, V. P.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, p. 458 - 463
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 3 p. 522 - 528
