sulfuric acid in methanol

1.1: 80 percent / trimethylorthoformate / sulfuric acid / methanol / Heating 2.1: SO2Cl2 / toluene / 2 h / -78 °C 2.2: collidine / toluene / 0.75 h 2.3: toluene / 0 - 70 °C 3.1: methanol / 4 h 4.1: 32.2 percent / pyridine / CH2Cl2 5.1: H2O2 / acetic acid 6.1: AcOH / Heating 7.1: 98 percent / H2SO4 / methanol View Scheme

1: 4-chloro-3-nitro-benzoic acid With caesium carbonate; Merrifield resin in N,N-dimethyl-formamide T=50°C; 24 h; 2: vinyl-magnesium bromide in tetrahydrofuran T=-40 - 0°C; Bartoli reaction; 3: methanol With sodium methylate in tetrahydrofuran T=25°C; 3 h;

1.1: SO2Cl2 / toluene / 2 h / -78 °C 1.2: collidine / toluene / 0.75 h 1.3: toluene / 0 - 70 °C 2.1: methanol / 4 h 3.1: 32.2 percent / pyridine / CH2Cl2 4.1: H2O2 / acetic acid 5.1: AcOH / Heating 6.1: 98 percent / H2SO4 / methanol View Scheme

1: 32.2 percent / pyridine / CH2Cl2 2: H2O2 / acetic acid 3: AcOH / Heating 4: 98 percent / H2SO4 / methanol View Scheme

1: methanol / 4 h 2: 32.2 percent / pyridine / CH2Cl2 3: H2O2 / acetic acid 4: AcOH / Heating 5: 98 percent / H2SO4 / methanol View Scheme

1: H2O2 / acetic acid 2: AcOH / Heating 3: 98 percent / H2SO4 / methanol View Scheme

in tetrahydrofuran; methanol T=25°C; 3 h; solid phase reaction;