5-氨基-1-苯基吡唑-4-甲酰胺合成路线 (共 37 条)
反应条件
sodium ethanolate in ethanol
6 h; Heating;
参考文献
Miyashita, Akira; Iijima, Chihoko; Higashino, Takeo; Matsuda, Hideaki
Heterocycles, 1990 , vol. 31, # 7 p. 1309 - 1314
反应条件
polyphosphate ester
T=110 - 120°C; 6 h;
参考文献
Reddy, K Hemender; Reddy, A Panduranga; Veeranagaiah, V
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1992 , vol. 31, # 3 p. 163 - 166
反应条件
sodium ethanolate in ethanol
P=15001.5 Torr; 0.0125 h; RefluxMicrowave irradiation; TimePressure;
参考文献
Devarakonda, Murty; Doonaboina, Raghava; Vanga, Sreedher; Vemu, Jahnavi; Boni, Sathoshini; Mailavaram, Raghu Prasad
Medicinal Chemistry Research, 2013 , vol. 22, # 3 p. 1090 - 1101
反应条件
[BsMIm][HSO4]
T=80°C; 0.0833333 h; neat (no solvent);
参考文献
Tavakoli-Hoseini, Niloofar; Moloudi, Raheleh; Davoodnia, Abolghasem; Shaker, Mohammad
Chinese Journal of Chemistry, 2011 , vol. 29, # 11 p. 2421 - 2426
反应条件
sodium ethanolate in ethanol
7 h; Heating;
参考文献
Miyashita, Akira; Iijima, Chihoko; Higashino, Takeo; Matsuda, Hideaki
Heterocycles, 1990 , vol. 31, # 7 p. 1309 - 1314
反应条件
PPA; Polyphosphoric acid (PPA)
T=110 - 120°C; 6 h;
参考文献
Reddy, K Hemender; Reddy, A Panduranga; Veeranagaiah, V
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1992 , vol. 31, # 3 p. 163 - 166
反应条件
2: PCl5; POCl3
3: aqueous KOH
View Scheme
参考文献
Meng, Fei; Huang, Manna; Zhu, Xinhai; Wan, Yiqian; Hou, Jing; Shao, Yong-Xian; Cai, Yonghong; Li, Zhe; Xu, Jie; Liu, Peiqing; Luo, Hai-Bin; Ke, Hengming; Wu, Pei-Ying
Journal of Medicinal Chemistry, 2012 , vol. 55, # 19 p. 8549 - 8558,10
反应条件
2: PCl5; POCl3
3: N2H4
View Scheme
参考文献
Cheng; Robins
Journal of Organic Chemistry, 1958 , vol. 23, p. 852,855
Journal of Organic Chemistry, 1959 , vol. 24, p. 1570
反应条件
1: sodium ethanolate / ethanol / 0.01 h / 15001.5 Torr / |Reflux; |Microwave irradiation
2: trichlorophosphate / 0.08 h / 120 °C / 22502.3 Torr / |Microwave irradiation
3: toluene / 20 °C
View Scheme
参考文献
Devarakonda, Murty; Doonaboina, Raghava; Vanga, Sreedher; Vemu, Jahnavi; Boni, Sathoshini; Mailavaram, Raghu Prasad
Medicinal Chemistry Research, 2013 , vol. 22, # 3 p. 1090 - 1101
反应条件
1: acetic acid anhydride
2: ethanol; NH3
View Scheme
参考文献
Cheng; Robins
Journal of Organic Chemistry, 1958 , vol. 23, p. 191,195