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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
50559-45-0
合成路线
(共 16 条)
223562-51-4
3-(1-丙炔-1-基)吡啶
→
反应条件
50559-45-0
反应条件
Mo(OSi(C6H5)3)3(C2H5OC2H5)(CC6H5) in toluene T=50°C; 2 h; Molecular sieveInert atmosphere;
参考文献
Yang, Haishen; Liu, Zhenning; Zhang, Wei
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 5 p. 885 - 890
626-55-1
3-溴吡啶
+
994-71-8
二(三正丁基甲锡烷基)乙炔
→
反应条件
50559-45-0
反应条件
tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane T=100°C; Stille coupling; 3 h; Inert atmosphere;
参考文献
Brown, Amy E.; Eichler, Barrett E.
Tetrahedron Letters, 2011 , vol. 52, # 16 p. 1960 - 1963
626-55-1
3-溴吡啶
+
471-25-0
丙炔酸
→
反应条件
50559-45-0
反应条件
Pd(TPPMS)2Cl2; diphenylphosphinobenzene-3-sulfonic acid sodium salt; octadecyl-trimethylammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene in water 20 h; Heating;
参考文献
Park, Kyungho; Bae, Goun; Park, Ahbyeol; Kim, Yong; Choe, Jaehoon; Song, Kwang Ho; Lee, Sunwoo
Tetrahedron Letters, 2011 , vol. 52, # 5 p. 576 - 580
626-55-1
3-溴吡啶
+
75-20-7
电石
→
反应条件
50559-45-0
反应条件
potassium carbonate; i-Pr2NPPh2; palladium diacetate in tetrahydrofuran T=65°C; 12 h;
参考文献
Zhang, Weiwei; Wu, Huayue; Liu, Zhiqing; Zhong, Ping; Zhang, Lin; Huang, Xiaobo; Cheng, Jiang
Chemical Communications, 2006 , # 46 p. 4826 - 4828
626-55-1
3-溴吡啶
+
115-19-5
2-甲基-3-丁炔-2-醇
→
反应条件
50559-45-0
反应条件
1: 2-methyl-but-3-yn-2-ol With copper(l) iodide; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride T=50°C; Sonogashira coupling; 1 h; 2: 3-bromo-pyridine With potassium hydroxide; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride T=110°C; Sonogashira coupling; 5 h;
参考文献
Novak, Zoltan; Nemes, Peter; Kotschy, Andras
Organic Letters, 2004 , vol. 6, # 26 p. 4917 - 4920
1120-90-7
3-碘吡啶
+
14630-40-1
二(三甲基甲硅烷基)乙炔
→
反应条件
50559-45-0
反应条件
pyrrolidine; copper(l) iodide; 4,4'-dichlorobenzophenone oxime derived palladacycle in 1-methyl-pyrrolidin-2-one T=110°C; sila-Sonogashira reaction; 8 h;
参考文献
Alonso, Diego A.; Botella, Luis; Najera; Pacheco, Ma. Carmen
Synthesis, 2004 , # 10 p. 1713 - 1718
626-55-1
3-溴吡啶
+
2510-23-8
3-乙炔基吡啶
→
反应条件
50559-45-0
反应条件
palladium
参考文献
Bosch; Barnes
New Journal of Chemistry, 2001 , vol. 25, # 11 p. 1376 - 1378
1120-90-7
3-碘吡啶
+
80673-00-3
3-(三甲硅乙炔基)吡啶
→
反应条件
50559-45-0
反应条件
tetrabutyl-ammonium chloride; sodium acetate; tris-(o-tolyl)phosphine; palladium diacetate in N,N-dimethyl-formamide T=100°C; Sonogashira coupling; 0.25 h; microwave irradiation;
参考文献
Sorensen, Ulrik S.; Pombo-Villar, Esteban
Tetrahedron, 2005 , vol. 61, # 10 p. 2697 - 2703
626-55-1
3-溴吡啶
+
107-04-0
1-溴-2-氯乙烷
→
反应条件
50559-45-0
反应条件
potassium hydroxide; 18-crown-6 ether; 1,4-di(diphenylphosphino)-butane; palladium diacetate in toluene T=100°C; 42 h;
参考文献
Abele, Edgars; Abele, Ramona; Arsenyan, Pavel; Lukevics, Edmunds
Tetrahedron Letters, 2003 , vol. 44, # 20 p. 3911 - 3913
626-55-1
3-溴吡啶
+
24202-81-1
→
反应条件
50559-45-0
反应条件
copper(l) iodide; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride T=80°C;
参考文献
Csekei, Marton; Novak, Zoltan; Kotschy, Andras
Tetrahedron, 2008 , vol. 64, # 6 p. 975 - 982
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