2,7-二甲基-2,4,6-辛三烯二醛合成路线 （共 26 条）
反应条件
sodium methylate in methanol T=0 - 25°C; 4 h;
参考文献
Helvetica Chimica Acta, , vol. 64, # 7 p. 2405 - 2418
反应条件
sodium hydride in dichloromethane; isopropyl alcohol
参考文献
Helvetica Chimica Acta, , vol. 61, # 7 p. 2609 - 2615
反应条件
1: 3,7,11-trimethyl-1,3,6,10-tetraene-dodecyl diethyl phosphonate With potassium tert-butylate in tetrahydrofuran; dimethyl sulfoxide T=5°C; 2 h; Inert atmosphere; 2: 2,7-dimethylocta-2,4,6-triene-1,8-dial in tetrahydrofuran; dimethyl sulfoxide T=5 - 25°C; 1.58 h; 3: in chloroform 2 h; RefluxInert atmosphere;
参考文献
University of Shaoxing; Zhejiang Medicine Co., Ltd., Xinchang Pharmaceutic al Factory; Lao, Xuejun; Shen, Runpu; Ye, Weidong; Song, Xiaohua; Liu, Luo; Wu, Chunlei; Sun, Xiongsheng; Hu, Siping
Patent: US2013/46114 A1, 2013 ;
Location in patent: Paragraph 0052-0055 ;
反应条件
potassium tert-butylate in tetrahydrofuran; chloroform; benzene
参考文献
Loyola University of Chicago
Patent: US5973179 A1, 1999 ;
反应条件
1: 3,7,11-trimethyl-1,4,6,10-dodecatetraenyl phosphoric acid di-methyl ester With potassium tert-butylate in tetrahydrofuran; dimethyl sulfoxide T=5°C; 2 h; Inert atmosphere; 2: 2,7-dimethyl-octa-2,4,6-triene-1,8-dial in tetrahydrofuran; dimethyl sulfoxide T=5 - 25°C; 1.58333 h; Inert atmosphere;
参考文献
SHAOXING UNIVERSITY; ZHEJIANG MEDICINE CO., LTD. XINCHANG; Shen, Runpu; LV, Chunlei; Jiang, Xiaoyue; Lao, Xuejun; Ye, Weidong; Liu, Luo; Song, Xiaohua; Wu, Chunlei
Patent: US2014/5442 A1, 2014 ;
Location in patent: Paragraph 0098; 0099; 0100; 0101; 0102; 0103; 0104 ;
反应条件
1: 3,7,11-trimethyl-1,4,6,10-dodecatetraenyl phosphonic acid diethyl ester With n-butyllithium in tetrahydrofuran; hexane T=-40°C; 2 h; Inert atmosphere; 2: 2,7-dimethyl-octa-2,4,6-triene-1,8-dial in tetrahydrofuran; hexane T=-40 - 30°C; 1.58333 h; Inert atmosphere; Product distribution / selectivity;
参考文献
Shaoxing University; Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory; SHEN, Runpu; LV, Chunlei; JIANG, Xiaoyue; LAO, Xuejun; YE, Weidong; LIU, Luo; SONG, Xiaohua; WU, Chunlei
Patent: EP2578564 A1, 2013 ;
Location in patent: Paragraph 0071; 0072; 0073; 0074 ;
反应条件
potassium tert-butylate in tetrahydrofuran; chloroform
参考文献
Loyola University of Chicago
Patent: US5952519 A1, 1999 ;
反应条件
sodium methylate in methanol; dichloromethane T=-10°C; 1 h;
参考文献
Rosenberger; McDougal; Bahr
Journal of Organic Chemistry, 1982 , vol. 47, # 11 p. 2130 - 2134
反应条件
potassium tert-butylate in tetrahydrofuran
参考文献
Loyola University of Chicago
Patent: US4916250 A1, 1990 ;
反应条件
tributylphosphine; phenyl isocyanate; tetrakis(triphenylphosphine) palladium(0) in acetonitrile 5 h; Heating;
参考文献
Okukado, Nobuhisa; Uchikawa, Osamu; Nakamura, Yukari
Chemistry Letters, 1988 , # 8 p. 1449 - 1452
