反应条件
1.1: NaOMe / methanol / 12 h / Heating
1.2: 99 percent / aq. NaOH / methanol / 4 h / Heating
2.1: H2 / Pd(OH)2/C / tetrahydrofuran; methanol / 24 h
3.1: 57.6 g / K2CO3 / dimethylformamide / 4 h / 20 °C
4.1: 65 percent / NBS / CCl4 / 12 h / 25 °C
5.1: 65 percent / aq. Na2CO3; Pd(PPh3)4 / ethanol; 1,2-dimethoxy-ethane / 6 h / 80 °C
View Scheme
参考文献
Harper, Steven; Pacini, Barbara; Avolio, Salvatore; Di Filippo, Marcello; Migliaccio, Giovanni; Laufer, Ralph; De Francesco, Raffaele; Rowley, Michael; Narjes, Frank
Journal of Medicinal Chemistry, 2005 , vol. 48, # 5 p. 1314 - 1317