5-甲氧基-2-甲基苯胺合成路线 （共 32 条）
参考文献
Copisarow
Journal of the Chemical Society, 1929 , p. 252
反应条件
in dichloromethane T=50°C; 2 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/49113 A1, 2009 ;
Location in patent: Page/Page column 20 ;
WO 2009/049113 A1
反应条件
1: tetrahydrofuran / Heating 2: 1a) s-BuLi, 2) DMF / 1a) THF, cyclohexane, -45 to -55 deg C, 30 min, 1b) -> -15 deg C, 60 min, 2) -45 deg C, 5 min 3: 12N HCl / tetrahydrofuran / 0.08 h / Ambient temperature 4: 98 percent / 15percent aq. NaOH / ethanol / 1 h / Heating View Scheme
参考文献
Clark; Muchowski; Fisher; Flippin; Repke; Souchet
Synthesis, 1991 , # 10 p. 871 - 878
反应条件
hydrogenchloride; HBF4; sodium nitrite in water
参考文献
Bristol-Myers Squibb Company
Patent: US6414002 B1, 2002 ;
反应条件
1: 1.) 10percent HCl, NaNO2, 2.) NaN3 / 1.) CH2Cl2, Hexane, Water, 5 deg C, 20 min, 2.) below 5 deg C, 3 h 2: anhydrous HF / CH2Cl2; hexane / 1 h / 5 °C 3: 60 percent / Isoamylnitrite / tetrahydrofuran / 5 h / Heating View Scheme
参考文献
Ng; Katzenellenbogen; Kilbourn
Journal of Organic Chemistry, 1981 , vol. 46, # 12 p. 2520 - 2528
反应条件
1: With sulfuric acid in water T=70°C; 2: With sodium nitrite in water T=70°C; 90 h;
参考文献
PARADIGM THERAPEUTICS LTD.
Patent: WO2007/582 A1, 2007 ;
Location in patent: Page/Page column 64-65 ;
WO 2007/000582 A1
反应条件
1: tetrahydrofuran / Heating 2: 1a) s-BuLi, 2) DMF / 1a) THF, cyclohexane, -45 to -55 deg C, 30 min, 1b) -> -15 deg C, 60 min, 2) -45 deg C, 5 min 3: 12N HCl / tetrahydrofuran / 0.08 h / Ambient temperature View Scheme
参考文献
Clark; Muchowski; Fisher; Flippin; Repke; Souchet
Synthesis, 1991 , # 10 p. 871 - 878
反应条件
1.1: potassium acetate / CHCl3 / 20 - 40 °C 1.2: isoamyl nitrite / CHCl3 / 60 °C 2.1: HCl / methanol / 80 °C View Scheme
参考文献
Ruechardt, Christoph; Hassmann, Volker
Liebigs Annalen der Chemie, 1980 , # 6 p. 908 - 927
反应条件
1.1: pyridine / 20 °C 1.2: pH 5 2.1: nitric acid; sulfuric acid / acetic acid / 3 h / 5 - 10 °C View Scheme
参考文献
Arora, Nidhi; Chen, Shaoqing; Hermann, Johannes Cornelius; Kuglstatter, Adreas; Labadie, Sharada Shenvi; Lin, Clara Jeou Jen; Lucas, Matthew C.; Moore, Amy Geraldine; Papp, Eva; Talamas, Francisco Xavier; Wanner, Jutta; Zhai, Yansheng
Patent: US2012/15962 A1, 2012 ;
US 20120015962 A1
反应条件
N-bromosuccinmide in chloroform T=5 - 20°C;
参考文献
Tetrahedron, , vol. 67, # 32 p. 5798 - 5805
