1-(2-呋喃基)-吡啶并(3,4-b)吲哚合成路线 （共 10 条）
反应条件
1: 3-ethenyl-1-phenylsulfonyl-1H-indole With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 1 h;
2: furan-2-carbonitrile in tetrahydrofuran
T=-78 - -10°C;
3: With hydroxylamine hydrochloride; sodium acetate in 1,2-dichloro-benzene
8 h; Heating;
参考文献
Kusurkar, Radhika S.; Goswami, Shailesh K.
Tetrahedron, 2004 , vol. 60, # 25 p. 5315 - 5318
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in 1,4-dioxane
Dehydrogenation; Heating;
参考文献
Foye, William O.; Wang, Xiping; Hongfu, Wang
Medicinal Chemistry Research, 1997 , vol. 7, # 3 p. 180 - 191
反应条件
1.1: 65 percent / t-BuOK / tetrahydrofuran
2.1: LDA / tetrahydrofuran / 1 h / -78 °C
2.2: tetrahydrofuran / -78 - -10 °C
2.3: 76 percent / NH2OH*HCl; AcONa / 1,2-dichloro-benzene / 8 h / Heating
View Scheme
参考文献
Kusurkar, Radhika S.; Goswami, Shailesh K.
Tetrahedron, 2004 , vol. 60, # 25 p. 5315 - 5318
反应条件
1: benzene / Heating
2: HCl / ethanol / 0 - 5 °C
3: 64 percent / 2,3-dichloro-5,6-dicyanobenzoquinone / dioxane / Heating
View Scheme
参考文献
Foye, William O.; Wang, Xiping; Hongfu, Wang
Medicinal Chemistry Research, 1997 , vol. 7, # 3 p. 180 - 191
反应条件
1: benzene / Heating
2: HCl / ethanol / 0 - 5 °C
3: 64 percent / 2,3-dichloro-5,6-dicyanobenzoquinone / dioxane / Heating
View Scheme
参考文献
Foye, William O.; Wang, Xiping; Hongfu, Wang
Medicinal Chemistry Research, 1997 , vol. 7, # 3 p. 180 - 191
反应条件
1: HCl / ethanol / 0 - 5 °C
2: 64 percent / 2,3-dichloro-5,6-dicyanobenzoquinone / dioxane / Heating
View Scheme
参考文献
Foye, William O.; Wang, Xiping; Hongfu, Wang
Medicinal Chemistry Research, 1997 , vol. 7, # 3 p. 180 - 191
反应条件
palladium on activated charcoal in xylene
参考文献
Severin; Brautigam
Chemische Berichte, 1973 , vol. 106, # 9 p. 2943 - 2949
反应条件
acetic acid in water
参考文献
Severin; Brautigam
Chemische Berichte, 1973 , vol. 106, # 9 p. 2943 - 2949
反应条件
phosphate buffer
T=37°C; Maillard reaction; pH=7.0; 672000 h;
参考文献
Masuda, Shuichi; Kanamori, Hisayuki; Kinae, Naohide
Bioscience, Biotechnology and Biochemistry, 2005 , vol. 69, # 11 p. 2232 - 2235
反应条件
in water
T=37°C; 1440 h;
参考文献
Kanamori; Morimoto; Kinae; Tomita
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3143 - 3144
