2-羟基-1-(1-哌啶基)乙酮合成路线 （共 7 条）
反应条件
4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
T=20°C; 16 h;
参考文献
Morin, Marie S.T.; Toumieux, Sylvestre; Compain, Philippe; Peyrat, Sandrine; Kalinowska-Tluscik, Justyna
Tetrahedron Letters, 2007 , vol. 48, # 48 p. 8531 - 8535
反应条件
in methanol
T=20°C; 168 h;
参考文献
Schurig, Volker; Betschinger, Frank
Bulletin de la Societe Chimique de France, 1994 , vol. 131, p. 555 - 560
参考文献
Rhone-Poulenc Sante
Patent: US4898871 A1, 1990 ;
参考文献
Rhone-Poulenc Sante
Patent: US4898871 A1, 1990 ;
反应条件
in dichloromethane
T=20°C; Inert atmosphere;
参考文献
Daryaee, Fereidoon; Kobarfard, Farzad; Khalaj, Ali; Farnia, Parisa
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 1 p. 289 - 295
反应条件
malonic acid in diethyl ether
2 h; Heating; Yield given;
参考文献
Ricci, Alfredo; Romanelli, M. Novella; Taddei, Maurizio; Seconi, Giancarlo; Shanzer, Abraham
Synthesis, 1983 , # 4 p. 319 - 322
反应条件
potassium tert-butylate; water in diethyl ether
参考文献
Kozikowski, Alan P.; Chen, Chinpiao; Ball, Richard G.
Tetrahedron Letters, 1990 , vol. 31, # 41 p. 5869 - 5872
