1: 3-hydroxy-1-butene With α-cyclohexylcyclohexanemethanamine; tetrabutylammomium bromide in N,N-dimethyl acetamide; water T=20°C; Heck reaction; 0.25 h; 2: 2-methoxy-6-bromo-naphthalene With 4'-hydroxyacetophenone oxime palladacycle catalyst in N,N-dimethyl acetamide; water T=120°C; Heck reaction; 9 h; Further stages.;
参考文献
Alacid, Emilio; Najera, Carmen
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 17-18 p. 2572 - 2584
1: 3-hydroxy-1-butene With α-cyclohexylcyclohexanemethanamine; tetrabutylammomium bromide in N,N-dimethyl acetamide T=20°C; Heck reaction; 0.25 h; 2: 2-methoxy-6-bromo-naphthalene With Kaiser oxime-derived complex on resin base in N,N-dimethyl acetamide T=120°C; Heck reaction; 14 h; Further stages. Title compound not separated from byproducts.;
参考文献
Alacid, Emilio; Najera, Carmen
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 17-18 p. 2572 - 2584
1: 3-hydroxy-1-butene With α-cyclohexylcyclohexanemethanamine; tetrabutylammomium bromide in N,N-dimethyl acetamide T=20°C; Heck reaction; 0.25 h; 2: 2-methoxy-6-bromo-naphthalene With Kaiser oxime-derived complex on resin base in N,N-dimethyl acetamide T=120°C; Heck reaction; 24 h; Further stages. Title compound not separated from byproducts.;
参考文献
Alacid, Emilio; Najera, Carmen
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 17-18 p. 2572 - 2584
1.1: magnesium; iodine / tetrahydrofuran / 5 h / |Reflux 1.2: 1.75 h / 10 - 90 °C 1.3: 1 h / 20 °C 2.1: sodium hydroxide / water / 4 h 3.1: hydrogen / ethyl acetate / 4 h / 20 °C / 760.05 Torr View Scheme
参考文献
Prabhakar; Reddy, C. Bakki; Reddy, Ch. Maheedhara; Nageshwar; Devi, A. Sivalakshmi; Babu, J. Moses; Vyas; Sarma; Reddy
Organic Process Research and Development, 1999 , vol. 3, # 2 p. 121 - 125
