2-(4-溴-3-氧代丁基)-1H-异吲哚-1,3(2H)-二酮合成路线 （共 12 条）
反应条件
1: With bromine in methanol T=20 - 25°C; 5 h; 2: in water 1 h; Reflux;
参考文献
Beliaev, Alexandre; Wahnon, Jorge; Russo, Domenico
Organic Process Research and Development, 2012 , vol. 16, # 4 p. 704 - 709
反应条件
water; hydrogen bromide; acetic acid
参考文献
Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Patent: US6727269 B1, 2004 ;
Location in patent: Page column 43-44 ;
US 6727269 B1
反应条件
1: NaOEt / ethanol; ethyl acetate / Heating 2: 1.) Br2, 2.) 10.0M aq. H2SO4 / 1.) MeOH, from 0 deg C to RT, 2.) RT View Scheme
参考文献
ACTELION PHARMACEUTICALS LTD; AISSAOUI, Hamed; BOSS, Christoph; RICHARD-BILDSTEIN, Sylvia; SIEGRIST, Romain
Patent: WO2014/6585 A1, 2014 ;
反应条件
thionyl chloride; hydrogen bromide
参考文献
Yang, Yajun; Feng, Ziming; Jiang, Jianshuang; Yang, Yanan; Pan, Xiandao; Zhang, Peicheng
Chemical and Pharmaceutical Bulletin, 2011 , vol. 59, # 8 p. 1016 - 1019
反应条件
2: SOCl2 3: 2) HBr View Scheme
参考文献
Yang, Yajun; Feng, Ziming; Jiang, Jianshuang; Yang, Yanan; Pan, Xiandao; Zhang, Peicheng
Chemical and Pharmaceutical Bulletin, 2011 , vol. 59, # 8 p. 1016 - 1019
反应条件
1: SOCl2 2: 2) HBr View Scheme
参考文献
Tolstikov, G. A.; Galin, F. Z.; Lakeev, S. N.; Khalilov, L. M.; Sultanova, V. S.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990 , vol. 39, # 3.2 p. 535 - 541
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990 , # 3 p. 612 - 620
反应条件
hydrogen bromide Yield given. Multistep reaction;
参考文献
Tolstikov, G. A.; Galin, F. Z.; Lakeev, S. N.; Khalilov, L. M.; Sultanova, V. S.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990 , vol. 39, # 3.2 p. 535 - 541
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990 , # 3 p. 612 - 620
反应条件
hydrogenchloride; thiourea
参考文献
Pfizer Inc.
Patent: US5037834 A1, 1991 ;
反应条件
potassium hydroxide
1 h; Reflux;
参考文献
Beliaev, Alexandre; Wahnon, Jorge; Russo, Domenico
Organic Process Research and Development, 2012 , vol. 16, # 4 p. 704 - 709
反应条件
in acetone
Ambient temperature;
参考文献
Zheng, Weiping; Nikulin, Victor I.; Konkar, Anish A.; Vansal, Sandeep S.; Shams, Gamal; Feller, Dennis R.; Miller, Duane D.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 12 p. 2287 - 2294
