2-氯-2',4'-二氟苯乙酮合成路线 （共 25 条）
反应条件
potassium carbonate in acetonitrile T=85°C; 0.833333 h; microwave irradiation;
参考文献
Tetrahedron Letters, , vol. 47, # 36 p. 6479 - 6483
反应条件
potassium carbonate in dichloromethane T=20°C; 24 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 45, # 12 p. 6020 - 6026
参考文献
Analytical Chemistry, , vol. 78, # 11 p. 3835 - 3838
反应条件
sodium acetate in N,N-dimethyl-formamide
参考文献
Schering Corporation
Patent: US5698557 A1, 1997 ;
反应条件
in N,N-dimethyl-formamide 4 h; Ambient temperature;
参考文献
Miyauchi, Hiroshi; Nakamura, Toshio; Ohashi, Naohito
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 9 p. 2625 - 2632
反应条件
BH3*N,N-diethylanilline; (S)-2-methyl-CBS-OAB in toluene T=40°C; 11 h;
参考文献
Chung, John Y. L.; Cvetovich, Raymond; Amato, Joseph; McWilliams, J. Christopher; Reamer, Robert; DiMichele, Lisa
Journal of Organic Chemistry, 2005 , vol. 70, # 9 p. 3592 - 3601
反应条件
1: potassium carbonate / tetrahydrofuran / 7 h / 20 °C 2: lead; zinc; iodine / tetrahydrofuran / -15 - 20 °C / Inert atmosphere 3: ammonium formate / palladium on carbon / toluene / 3 h / 80 °C 4: acetone; methanol / 1 h / Reflux 5: sodium hydrogencarbonate / dichloromethane / 0.5 h View Scheme
参考文献
Dongkook Pharmaceutical Co., Ltd.
Patent: US2013/5973 A1, 2013 ;
反应条件
1.1: diethyl zinc / Ni(acac)2 / CH2Cl2; hexane / 0.5 h / 0 °C 1.2: CH2Cl2; hexane / -30 °C 2.1: 71.6 percent / aq. H2O2; LiOH*H2O / tetrahydrofuran / -10 - 0 °C 3.1: 89.3 percent / dimethylformamide / 0 - 60 °C View Scheme
参考文献
Yu, Luo-Ting; Ho, Meng-Tsung; Chang, Ching-Yao; Yang, Teng-Kuei
Tetrahedron Asymmetry, 2007 , vol. 18, # 8 p. 949 - 962
反应条件
sodium hydrogencarbonate in toluene 4 h; Reflux;
参考文献
Borate, Hanumant B.; Sawargave, Sangmeshwer P.; Maujan, Suleman R.
Tetrahedron Letters, 2009 , vol. 50, # 47 p. 6562 - 6566
反应条件
1.1: magnesium / tert-butyl methyl ether / 4 h / 55 °C 1.2: -10 - 0 °C 1.3: 3 h / 25 - 50 °C 2.1: sodium hydroxide / dimethyl sulfoxide / 5 h / 25 - 30 °C 3.1: water; lithium chloride; sodium tetrahydroborate / isopropyl alcohol / 20 h / -5 - 30 °C 3.2: pH 1 View Scheme
参考文献
SANDOZ AG; WILHELM, Thorsten; LANGNER, Martin
Patent: WO2012/172015 A1, 2012 ;
