8-苯基-1,4-二噁螺[4.5]癸烷-8-甲腈合成路线 （共 16 条）
反应条件
1: sodium; toluene; ethanol View Scheme
参考文献
Horning et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 773
反应条件
diethyl ether; ammonia; sodium
参考文献
Horning et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 773
参考文献
Bergmann; Yaroslavsky
Journal of the American Chemical Society, 1950 , vol. 81, p. 2772,2774
参考文献
Horning et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 773
反应条件
1: 77 percent / KOH / ethane-1,2-diol; H2O / 48 h / Heating 2: 92 percent / acetic acid / 24 h / Heating 3: 1.) NaOH / 1.) EtOH, HMPT, 10 min, 2.) 50 deg C, 2 h View Scheme
参考文献
Schneider, Woldemar; Krombholz, Gottfried
Archiv der Pharmazie (Weinheim, Germany), 1980 , vol. 313, # 6 p. 487 - 498
反应条件
acetic acid 20 h; Heating;
参考文献
Schneider, Woldemar; Krombholz, Gottfried
Archiv der Pharmazie (Weinheim, Germany), 1980 , vol. 313, # 6 p. 487 - 498
反应条件
1: 77 percent / KOH / ethane-1,2-diol; H2O / 48 h / Heating
2: 92 percent / acetic acid / 24 h / Heating
View Scheme
参考文献
Schneider, Woldemar; Krombholz, Gottfried
Archiv der Pharmazie (Weinheim, Germany), 1980 , vol. 313, # 6 p. 487 - 498
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
2 h; Heating / reflux;
参考文献
Johnson, James A.; Lloyd, John; Kover, Alexander
Patent: US2005/250783 A1, 2005 ;
Location in patent: Page/Page column 18 ;
反应条件
1: With diisobutylaluminium hydride in toluene
T=50°C; 0.222222 h; Flow reactor;
2: With water; tartaric acid disodium salt in toluene
T=0°C; chemoselective reaction;
参考文献
Munoz, Juan De M.; Alcazar, Jesus; De La Antonio, Hoz; Diaz-Ortiz, Angel
Tetrahedron Letters, 2011 , vol. 52, # 46 p. 6058 - 6060
反应条件
toluene-4-sulfonic acid in toluene
3.5 h; Heating;
参考文献
Grunenthal GMBH
Patent: US2009/247530 A1, 2009 ;
Location in patent: Page/Page column 51; 52 ;
US 20090247530 A1
