(R)-(−)-环氧氯丙烷合成路线 （共 62 条）
反应条件
sodium hydroxide in water; toluene
T=69 - 71°C; 6 h; Product distribution / selectivity;
参考文献
ASTRAZENECA AB
Patent: WO2006/137773 A1, 2006 ;
Location in patent: Page/Page column 16-20 ;
反应条件
potassium carbonate in acetonitrile
参考文献
AstraZeneca AB
Patent: US6559143 B1, 2003 ;
US 6559143 B1
反应条件
caesium carbonate in acetonitrile
3 h; Reflux;
参考文献
SANOFI-AVENTIS
Patent: US2011/77257 A1, 2011 ;
Location in patent: Page/Page column 11 ;
反应条件
1: 4-(trifluoromethyl)phenol With potassium carbonate in butanone
T=20°C; 0.166667 h; Inert atmosphereSchlenk technique;
2: (R)-(-)-epichlorohydrin in butanone
T=90°C; 15 h; Inert atmosphereSchlenk technique;
参考文献
Park, Jung-Eun; Ji, Wan Keun; Jang, Jae Wan; Pae, Ae Nim; Choi, Keehyun; Choi, Ki Hang; Kang, Jahyo; Roh, Eun Joo
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1887 - 1890
反应条件
caesium carbonate in acetonitrile
Reflux;
参考文献
Sun, Dianqing; Scherman, Michael S.; Jones, Victoria; Hurdle, Julian G.; Woolhiser, Lisa K.; Knudson, Susan E.; Lenaerts, Anne J.; Slayden, Richard A.; McNeil, Michael R.; Lee, Richard E.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 10 p. 3588 - 3594
反应条件
sodium hydroxide; N-benzyl-N,N,N-trimethyl-ammonium chloride in water; toluene
T=0 - 20°C; 35.67 h;
参考文献
DAISO CO., LTD.
Patent: EP1508568 A1, 2005 ;
Location in patent: Page 5 ;
反应条件
1: in tert-butyl alcohol
T=0 - 20°C;
2: With potassium tert-butylate in tetrahydrofuran; tert-butyl alcohol
T=10 - 20°C;
参考文献
SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.
Patent: US2012/295887 A1, 2012 ;
Location in patent: Page/Page column 5-6 ;
反应条件
potassium carbonate in acetonitrile
Heating; Title compound not separated from byproducts.;
参考文献
Shivani; Pujala, Brahmam; Chakraborti, Asit K.
Journal of Organic Chemistry, 2007 , vol. 72, # 10 p. 3713 - 3722
反应条件
sodium hydroxide
1) DMF, 30 min, 2) DMF, 7.5 h, r.t.; Yield given. Multistep reaction;
参考文献
Krause; Schmidt; Foken
Pharmazie, 1992 , vol. 47, # 11 p. 838 - 841
反应条件
caesium carbonate in acetonitrile
Reflux;
参考文献
Sun, Dianqing; Scherman, Michael S.; Jones, Victoria; Hurdle, Julian G.; Woolhiser, Lisa K.; Knudson, Susan E.; Lenaerts, Anne J.; Slayden, Richard A.; McNeil, Michael R.; Lee, Richard E.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 10 p. 3588 - 3594
