5,7-二甲基-[1,2,4]噻唑并[1,5-a]嘧啶-2-氢硫化物合成路线 (共 9 条)
反应条件
piperidine; acetic acid 20 h; Reflux;
参考文献
European Journal of Medicinal Chemistry, , vol. 64, p. 54 - 61
反应条件
piperidine; acetic acid 10 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 25, # 4 p. 420 - 426
反应条件
1: 2,5-dithiobiurea With hydrogenchloride; sodium hydroxide in water 2: acetylacetone
参考文献
Asian Journal of Chemistry, , vol. 23, # 2 p. 602 - 608
反应条件
1: 2-mercapto-5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine With sodium hydroxide in water
0.5 h; Heating;
2: chloroacetic acid in water
5 h; Heating;
参考文献
Yang, Guangfu; Xu, Li; Lu, Aihong
Heteroatom Chemistry, 2001 , vol. 12, # 6 p. 491 - 496
反应条件
sodium hydroxide in methanol; water
参考文献
The Dow Chemical Company
Patent: US4818273 A1, 1989 ;
参考文献
Novinson; Springer; O'Brien; Scholten; Miller; Robins
Journal of Medicinal Chemistry, 1982 , vol. 25, # 4 p. 420 - 426
反应条件
potassium hydroxide
1.25 h;
参考文献
Novinson; Springer; O'Brien; Scholten; Miller; Robins
Journal of Medicinal Chemistry, 1982 , vol. 25, # 4 p. 420 - 426
反应条件
sodium hydroxide; tetrabutylammomium bromide in methanol; water
参考文献
Chen, Wen-Bin; Jin, Gui-Yu
Heteroatom Chemistry, 2003 , vol. 14, # 7 p. 607 - 611