α-乙酰基-γ-丁内酯合成路线 （共 116 条）
反应条件
toluene-4-sulfonic acid in toluene
Heating;
参考文献
Lehmann
Archiv der Pharmazie, 1984 , vol. 317, # 2 p. 126 - 133
反应条件
toluene-4-sulfonic acid in toluene
Heating;
参考文献
Lehmann
Archiv der Pharmazie, 1984 , vol. 317, # 2 p. 126 - 133
反应条件
1: 76 percent / p-toluenesulfonic acid / toluene / Heating
2: 65 percent / H2 / PtO2 / ethanol / 15 h / 1650.1 - 2100.2 Torr / Ambient temperature
View Scheme
参考文献
Lehmann
Archiv der Pharmazie, 1984 , vol. 317, # 2 p. 126 - 133
反应条件
1: 74 percent / p-toluenesulfonic acid / toluene / Heating
2: 76 percent / H2 / PtO2 / ethanol / 15 h / 1650.1 - 2100.2 Torr / Ambient temperature
View Scheme
参考文献
Lehmann
Archiv der Pharmazie, 1984 , vol. 317, # 2 p. 126 - 133
反应条件
1: 76 percent / p-toluenesulfonic acid / toluene / Heating
2: 65 percent / H2 / PtO2 / ethanol / 15 h / 1650.1 - 2100.2 Torr / Ambient temperature
3: 2.) aq. HCl / 1.) benzene, ether, 50 deg C, 12 h
View Scheme
参考文献
Lehmann
Archiv der Pharmazie, 1984 , vol. 317, # 2 p. 126 - 133
反应条件
sodium hydride in N,N-dimethyl-formamide; benzene
5 h; Heating;
参考文献
Jackson, Andrew C.; Goldman, Boris E.; Snider, Barry B.
Journal of Organic Chemistry, 1984 , vol. 49, # 21 p. 3988 - 3994
反应条件
1.1: nBuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 68 percent / tetrahydrofuran; hexane / 0.33 h / -78 °C
2.1: 95 percent / PPh3 / Pd(OAc)2 / benzene; 1,2-dichloro-ethane; pentane / 4 h / 50 °C
View Scheme
参考文献
Capuzzi, Marinella; Gambacorta, Augusto; Gasperi, Tecla; Loreto, M. Antonietta; Tardella, P. Antonio
European Journal of Organic Chemistry, 2006 , # 22 p. 5076 - 5082
反应条件
in butan-1-ol
5 h; Heating;
参考文献
American Cyanamid Company
Patent: US4577018 A1, 1986 ;
参考文献
Malawska, Barbara; Gorczyca, Maria
Acta Poloniae Pharmaceutica, 1994 , vol. 51, # 1 p. 63 - 68
反应条件
1: 92.9 percent / toluene / 24 h / Heating
2: 94.7 percent / POCl3 / 4 h / Heating
View Scheme
参考文献
Badawey; Kappe
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 10 p. 815 - 822
