3-(1H-咪唑-4-基)吡啶合成路线 （共 19 条）
反应条件
nitric acid; sodium nitrite in water T=5 - 35°C;
参考文献
BIAL - PORTELA and Cª, S.A.; RUSSO, Domenico; WAHNON, Jorge Bruno Reis; MATON, William; ESZENYI, Tibor
Patent: WO2014/17938 A2, 2014 ;
Location in patent: Page/Page column 66 ;
反应条件
formaldehyd; ammonia in water; dimethyl sulfoxide T=-3 - 30°C;
参考文献
Sumika Fine Chemicals Co., Ltd.
Patent: US6649768 B1, 2003 ;
Location in patent: Page/Page column 7 ;
参考文献
Aventis Pharma S.A.
Patent: US6353108 B1, 2002 ;
Location in patent: Page column 3-4 ;
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethylene glycol dimethyl ether T=90°C; Suzuki coupling; 14 h;
参考文献
Denton, Travis T.; Zhang, Xiaodong; Cashman, John R.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 1 p. 224 - 239
反应条件
T=100°C; Bredereck Imidazole Synthesis; 0.25 h;
参考文献
Liu, Cong; Nie, Yijiao; Yao, Guowei; Dai, Rongji; Deng, Yulin
Journal of Chemical Research, 2014 , vol. 38, # 4 p. 208 - 210
反应条件
T=170 - 180°C; Inert atmosphere;
参考文献
Kumar, Sanjeev; Jaller, Daniel; Patel, Bhumika; LaLonde, Judith M.; DuHadaway, James B.; Malachowski, William P.; Prendergast, George C.; Muller, Alexander J.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 16 p. 4968 - 4977
反应条件
1.1: n-BuLi / toluene; hexane; tetrahydrofuran / -50 °C 1.2: triisopropyl borate / toluene; tetrahydrofuran; hexane / -50 - -15 °C 1.3: 73 percent / aq. NaOH / toluene; tetrahydrofuran; hexane 2.1: 39 percent / Pd(PPh3)4; aq. Na2CO3 / 1,2-dimethoxy-ethane / 14 h / 90 °C View Scheme
参考文献
Denton, Travis T.; Zhang, Xiaodong; Cashman, John R.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 1 p. 224 - 239
参考文献
Dolby, Lloyd J.; Esfandiari, Shervin; Garst, Michael E.
Patent: US2005/101785 A1, 2005 ;
Location in patent: Page/Page column 6 ;
反应条件
hydrogenchloride in ethanol 0.75 h; Heating;
参考文献
Primas, Nicolas; Mahatsekake, Clement; Bouillon, Alexandre; Lancelot, Jean-Charles; Oliveira Santos, Jana Sopkova-de; Lohier, Jean-Francois; Rault, Sylvain
Tetrahedron, 2008 , vol. 64, # 20 p. 4596 - 4601
反应条件
1.1: hydroxylamine hydrochloride / methanol / 1 h / |Reflux 1.2: 1 h / |Reflux 2.1: pyridine / 5 - 25 °C 2.2: 10 - 25 °C 2.3: 3 h / 80 °C 3.1: water / 15 - 90 °C 4.1: sodium nitrite; nitric acid / water / 5 - 35 °C View Scheme
参考文献
BIAL - PORTELA and Cª, S.A.; RUSSO, Domenico; WAHNON, Jorge Bruno Reis; MATON, William; ESZENYI, Tibor
Patent: WO2014/17938 A2, 2014 ;
