3,3'-二溴-2,2'-联噻吩合成路线 （共 19 条）
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran T=0°C; 2 h; Inert atmosphere; 2: With zinc(II) chloride in tetrahydrofuran 0.25 h; Inert atmosphere; Further stages;
参考文献
Evenson, Sean J.; Rasmussen, Seth C.
Organic Letters, 2010 , vol. 12, # 18 p. 4054 - 4057
反应条件
hydrogenchloride; water; acetic acid; zinc in ethanol 2 h; Reflux;
参考文献
Letizia, Joseph A.; Cronin, Scott; Ortiz, Rocio Ponce; Facchetti, Antonio; Ratner, Mark A.; Marks, Tobin J.
Chemistry - A European Journal, 2010 , vol. 16, # 6 p. 1911 - 1928
反应条件
1: With n-butyllithium T=-78°C; 2: With copper dichloride T=-78 - 20°C;
参考文献
Allared, Fredrik; Hellberg, Jonas; Remonen, Tommi
Tetrahedron Letters, 2002 , vol. 43, # 8 p. 1553 - 1554
反应条件
1: 77 percent / bromine / acetic acid; CHCl3 / 30.5 h 2: 90 percent / zinc; HCl / ethanol; H2O; acetic acid / 2 h / Heating View Scheme
参考文献
Leriche, Philippe; Raimundo, Jean-Manuel; Turbiez, Mathieu; Monroche, Vincent; Allain, Magali; Sauvage, Francois-Xavier; Roncali, Jean; Frere, Pierre; Skabara, Peter J.
Journal of Materials Chemistry, 2003 , vol. 13, # 6 p. 1324 - 1332
反应条件
copper dichloride in diethyl ether T=-78°C; 2 h;
参考文献
Dahlmann, Uwe; Neidlein, Richard
Helvetica Chimica Acta, 1996 , vol. 79, # 3 p. 755 - 766
反应条件
copper(II) nitrate in tetrahydrofuran T=23°C; Decomposition; coupling;
参考文献
Harada, Genta; Yoshida, Masato; Iyoda, Masahiko
Chemistry Letters, 2000 , # 2 p. 160 - 161
反应条件
1: With n-butyllithium in diethyl ether T=-78°C; 0.666667 h; 2: With (PhSO2)2S in diethyl ether T=-78 - 20°C;
参考文献
Allared, Fredrik; Hellberg, Jonas; Remonen, Tommi
Tetrahedron Letters, 2002 , vol. 43, # 8 p. 1553 - 1554
反应条件
Pd2dba3*CH2Cl2; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate in toluene T=110°C; Buchwald-Hartwig reaction; 7 h; Product distribution; Further Variations:ReagentsSolventsTemperaturesconcentration;
参考文献
Koeckelberghs, Guy; De Cremer, Lieven; Vanormelingen, Wouter; Dehaen, Wim; Verbiest, Thierry; Persoons, Andre; Samyn, Celest
Tetrahedron, 2005 , vol. 61, # 3 p. 687 - 691
反应条件
palladium diacetate; tri-tert-butyl phosphine in toluene T=110°C;
参考文献
Koeckelberghs, Guy; De Cremer, Lieven; Vanormelingen, Wouter; Dehaen, Wim; Verbiest, Thierry; Persoons, Andre; Samyn, Celest
Tetrahedron, 2005 , vol. 61, # 3 p. 687 - 691
反应条件
1.1: n-BuLi / hexane; tetrahydrofuran / 1.5 h / -78 °C 1.2: 68 percent / hexane; tetrahydrofuran / -78 - 20 °C 2.1: 91 percent / NBS / dimethylformamide / 0.17 h / 20 °C View Scheme
参考文献
Usta, Hakan; Lu, Gang; Facchetti, Antonio; Marks, Tobin J.
Journal of the American Chemical Society, 2006 , vol. 128, # 28 p. 9034 - 9035
