2,3-二甲基丁酰基氯化物合成路线 （共 13 条）
反应条件
water in acetonitrile T=1.1 - 15.7°C; KineticsActivation energy;
参考文献
Regan, Andrew C.; Watt, C. Ian F.
Journal of Physical Organic Chemistry, 2007 , vol. 20, # 3 p. 180 - 189
反应条件
1: dichloromethane / 20 °C / |Cooling with ice
2: lithium aluminium tetrahydride / diethyl ether / 20 °C
3: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; potassium bromide; sodium hypochlorite; sodium hydrogencarbonate / water; dichloromethane / -10 - 15 °C
View Scheme
参考文献
Daw, Graham; Regan, Andrew C.; Watt, C. Ian F.; Wood, Evan
Journal of Physical Organic Chemistry, 2013 , vol. 26, # 12 p. 1048 - 1057
参考文献
Warthen; Klun; DeVilbiss
Journal of Chemical Ecology, 1996 , vol. 22, # 7 p. 1315 - 1324
反应条件
triethylamine in diethyl ether
T=22°C; 16 h;
参考文献
Jochims,J.C.; Lambrecht,J.
Tetrahedron, 1984 , vol. 40, p. 893
参考文献
Spielman; Geiszler; Close
Journal of the American Chemical Society, 1948 , vol. 70, p. 4189
反应条件
tetrachloromethane; 4-(N,N-dimethlyamino)pyridine; Fonderma
3 h; Heating;
参考文献
Stofer, Edmond; Lion, Claude
Bulletin des Societes Chimiques Belges, 1987 , vol. 96, # 8 p. 623 - 628
参考文献
Jenny, Christjohannes; Heimgartner, Heinz
Helvetica Chimica Acta, 1986 , vol. 69, p. 374 - 388
反应条件
in dichloromethane
T=25°C; 12 h;
参考文献
Kaufmann, Dan; Bialer, Meir; Shimshoni, Jakob Avi; Devor, Marshall; Yagen, Boris
Journal of Medicinal Chemistry, 2009 , vol. 52, # 22 p. 7236 - 7248
反应条件
1: 81.9 percent / BuLi; diisopropylamine; hexamethylphosphoramide / tetrahydrofuran
2: SOCl2
View Scheme
参考文献
Warthen; Klun; DeVilbiss
Journal of Chemical Ecology, 1996 , vol. 22, # 7 p. 1315 - 1324
反应条件
1: NaH / tetrahydrofuran
2: 1.) saponification, 2.) decarboxylation
3: 95 percent / thionyl chloride
View Scheme
参考文献
Jenny, Christjohannes; Heimgartner, Heinz
Helvetica Chimica Acta, 1986 , vol. 69, p. 374 - 388
