2-[(10-溴癸基)氧基]四氢-2H-吡喃合成路线 （共 50 条）
反应条件
1: [1,3-bis(diphenylphosphino) propane] dichloronickel(II); magnesium / tetrahydrofuran; diethyl ether
2: toluene-4-sulfonic acid / methanol
3: N-bromosuccinmide / N,N-dimethyl-formamide
View Scheme
参考文献
Watanabe, Mari; Tsuchiya, Kazuhiko; Shinnai, Toshinobu; Kijima, Masashi
Macromolecules, 2012 , vol. 45, # 4 p. 1825 - 1832
反应条件
1.1: n-butyllithium / tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane / 0.5 h / -60 °C
1.2: -20 - 20 °C
2.1: Jone's reagent / acetone / 0 - 4 °C
3.1: sulfuric acid / 20 °C
View Scheme
参考文献
Fu, Yu; Weng, Yue; Hong, Wen-Xu; Zhang, Qinghai
Synlett, 2011 , # 6 p. 809 - 812
反应条件
1: CuCl / tetrahydrofuran / 5 h / Heating
2: p-TsOH / methanol / 8 h / Ambient temperature
View Scheme
参考文献
Miyakoshi, Tetsuo; Du, Yumin; Kumanotani, Ju
Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 3 p. 1054 - 1056
反应条件
toluene-4-sulfonic acid
0.5 h;
参考文献
Teubner, Achim; Gerlach, Hans
Liebigs Annalen der Chemie, 1993 , # 2 p. 161 - 166
反应条件
1: 89 percent / aq. HBr / toluene / 16 h / Heating
2: 80 percent / PPTS / CH2Cl2 / 16 h / 20 °C
View Scheme
参考文献
Grube, Achim; Timm, Christoph; Koeck, Matthias
European Journal of Organic Chemistry, 2006 , # 5 p. 1285 - 1295
反应条件
carbon tetrabromide; triphenylphosphine in tetrahydrofuran
T=20°C; 12 h;
参考文献
Hirst, David; Diele, Siegmar; Laschat, Sabine; Nimtz, Manfred
Helvetica Chimica Acta, 2001 , vol. 84, # 5 p. 1190 - 1196
反应条件
1: 92 percent / aq. HCl / diethyl ether / 18 h / Ambient temperature
2: 1.) Mg, 2.) dilithium tetrachlorocuprate / 1.) THF, 2 h, 2.) 0 deg C, 2 h
View Scheme
参考文献
Michelot, Didier
Synthesis, 1983 , # 2 p. 130 - 134
反应条件
2: 48percent HBr / H2O / 60 h / Heating
3: 11.9 g / TsOH / diethyl ether / 26 h / Ambient temperature
View Scheme
参考文献
Odinokov; Botsman; Gladysheva
Chemistry of Natural Compounds, 1996 , vol. 32, # 3 p. 381 - 383
反应条件
pyridinium p-toluenesulfonate in dichloromethane
参考文献
Narihiro, Harunori; Dai, Xiaoman; Goto, Hiromasa; Akagi, Kazuo
Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 2001 , vol. 365, p. 363 - 371
反应条件
dilithium tetrachlorocuprate; magnesium
1.) THF, 2 h, 2.) 0 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Michelot, Didier
Synthesis, 1983 , # 2 p. 130 - 134
