N-(2-苯基乙基)环己胺合成路线 （共 19 条）
反应条件
hydrogenchloride in diethyl ether; hexane Inert atmosphere;
参考文献
Wiese, Stefan; Badiei, Yosra M.; Gephart, Raymond T.; Mossin, Susanne; Varonka, Matthew S.; Melzer, Marie M.; Meyer, Karsten; Cundari, Thomas R.; Warren, Timothy H.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 47 p. 8850 - 8855
反应条件
1: in methanol
T=64°C; Borch Reduction; 3 h;
2: With sodium cyanoborohydride in methanol; ethanol
T=20 - 64°C; Borch Reduction; 5 h;
参考文献
Ross, Nathan T.; Deane, Rashid; Perry, Sheldon; Miller, Benjamin L.
Tetrahedron, 2013 , vol. 69, # 36 p. 7653 - 7658
反应条件
potassium carbonate; [{(η5-C5Me5)IrCl}2(μ-Cl)2] in toluene
T=110°C; 17 h;
参考文献
Fujita, Ken-Ichi; Li, Zhenzi; Ozeki, Naohiro; Yamaguchi, Ryohei
Tetrahedron Letters, 2003 , vol. 44, # 13 p. 2687 - 2690
反应条件
naphthalene; water; lithium in tetrahydrofuran
1.) -78 deg C, 6 h, 2.) -78 - 20 deg C, 3 h;
参考文献
Almena, Juan; Foubelo, Francisco; Yus, Miguel
Journal of Organic Chemistry, 1994 , vol. 59, # 11 p. 3210 - 3215
反应条件
1: in tetrahydrofuran; methanol
1 h; Molecular sieve;
2: With sodium cyanoborohydride in tetrahydrofuran; methanol
24 h;
参考文献
NOVO NORDISK A/S
Patent: WO2007/6814 A1, 2007 ;
Location in patent: Page/Page column 78-79 ;
WO 2007/006814 A1
反应条件
triethylamine in N,N-dimethyl-formamide
T=20 - 25°C; 18 h; Molecular sieve; chemoselective reaction;
参考文献
Bhattacharyya, Shubhankar; Pathak, Uma; Mathur, Sweta; Vishnoi, Subodh; Jain, Rajeev
RSC Advances, 2014 , vol. 4, # 35 p. 18229 - 18233
反应条件
copper(II) sulfate in methanol; water
1.5 h; Heating;
参考文献
Katritzky, Alan R.; Latif, Muhammad; Urogdi, Laszlo
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , p. 667 - 672
反应条件
lithium aluminium tetrahydride in diethyl ether
30 h; Heating;
参考文献
Takamatsu; Sekiya
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 3 p. 616 - 622
反应条件
in toluene
T=140°C; P=3800.26 Torr; 49 h; Inert atmosphere;
参考文献
He, Lin; Lou, Xia-Bing; Ni, Ji; Liu, Yong-Mei; Cao, Yong; He, He-Yong; Fan, Kang-Nian
Chemistry - A European Journal, 2010 , vol. 16, # 47 p. 13965 - 13969
反应条件
nickel
T=110 - 130°C; P=15200 Torr; Hydrogenation;
参考文献
v.Braun; Blessing; Zobel
Chemische Berichte, 1923 , vol. 56, p. 1990
Chemische Berichte, 1923 , vol. 56, p. 1999
