3-氯-L-丙氨酸盐酸盐合成路线 （共 11 条）
反应条件
hydrogenchloride; thionyl chloride in ethylene glycol dimethyl ether T=20 - 50°C; 10 h;
参考文献
Kaneka Corporation
Patent: US6372941 B1, 2002 ;
Location in patent: Example 6 ;
反应条件
hydrogenchloride 0.0833333 h;
参考文献
Arnold,L.D.; May,R.G.; Vederas,J.C.
Journal of the American Chemical Society, 1988 , vol. 110, p. 2237
反应条件
thionyl chloride in 1,4-dioxane T=20 - 60°C; 3 h;
参考文献
Kaneka Corporation
Patent: US6372941 B1, 2002 ;
Location in patent: Example 9 ;
参考文献
Deboves; Montalbetti; Jackson
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 16 p. 1876 - 1884
反应条件
sodium hydroxide T=20°C; 24 h;
参考文献
Shiraiwa, Tadashi; Nakagawa, Kazuo; Kanemoto, Norito; Kinda, Tomohiro; Yamamoto, Hiroki
Chemical and Pharmaceutical Bulletin, 2002 , vol. 50, # 8 p. 1081 - 1085
反应条件
selenium; sodium tetrahydroborate T=37°C; pH=9;
参考文献
Xie, Yang; Short, Megan D.; Cassidy, Pamela B.; Roberts, Jeanette C.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 22 p. 2911 - 2915
反应条件
1: dimethyl diselenide With sodium hydroxide; sodium tetrahydroborate in DMF (N,N-dimethyl-formamide); water T=5 - 45°C; 2 h; 2: β-chloro-L-alanine hydrochloride in DMF (N,N-dimethyl-formamide); water T=5 - 45°C; 2.5 h;
参考文献
Sami Labs Limited
Patent: US6794537 B1, 2004 ;
Location in patent: Page column 5-6 ;
反应条件
selenium; sodium tetrahydroborate T=37°C; pH=9;
参考文献
Xie, Yang; Short, Megan D.; Cassidy, Pamela B.; Roberts, Jeanette C.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 22 p. 2911 - 2915
反应条件
1: (E)-1-(benzylthio)-1-propene With ammonia; sodium in diethyl ether T=-42°C; 2: β-chloro-L-alanine hydrochloride in tetrahydrofuran T=0 - 20°C; 18 h; 3: With acetic acid in tetrahydrofuran; water pH=5 - 6;
参考文献
Lee, Sangku; Kim, Jae Nyoung; Choung, Dong-Ho; Lee, Hyeong Kyu
Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 1 p. 319 - 320
反应条件
1: With hydrogenchloride in water T=20°C; 0.166667 h; 2: With lithium hydroxide in water T=0 - 10°C; pH=5.5;
参考文献
Kaneka Corporation
Patent: US6372941 B1, 2002 ;
Location in patent: Example 3 ;
