5-溴-2-(硫代甲基)嘧啶合成路线 （共 11 条）
反应条件
1: 2,5-dibromo-pyridine With n-butyllithium in hexane; toluene T=-78°C; Metallation; 2 h; 2: dimethyl-disulfide in hexane; toluene T=-78°C; Substitution; 1 h;
参考文献
Wang, Xin; Rabbat, Philippe; O'Shea, Paul; Tillyer, Richard; Grabowski; Reider, Paul J.
Tetrahedron Letters, 2000 , vol. 41, # 22 p. 4335 - 4338
反应条件
1: 3-bromopyridinetrifluoroborate With lithium diisopropyl amide in diethyl ether T=-78°C; Inert atmosphere; 2: dimethyl-disulfide in diethyl ether T=-78°C; Inert atmosphere; 3: With water
参考文献
Dhau, Jaspreet S.; Singh, Amritpal; Kasetti, Yoganjaneyulu; Bhatia, Sonam; Bharatam, Parsad V.; Brandao, Paula; Felix, Vitor; Singh, Kamal N.
Tetrahedron, 2013 , vol. 69, # 48 p. 10284 - 10291
反应条件
in N,N-dimethyl-formamide T=0°C; 3.5 h; Inert atmosphere; Product distribution / selectivity;
参考文献
Daiichi Sankyo Company, Limited
Patent: EP2239253 A1, 2010 ;
Location in patent: Page/Page column 98 ;
EP 2239253 A1
反应条件
in water; ethyl acetate; N,N-dimethyl-formamide
参考文献
X-Ceptor Therapeutics, Inc.
Patent: US2005/80111 A1, 2005 ;
US 20050080111 A1
反应条件
2-mercaptoethanesulphonic acid sodium salt in N,N-dimethyl-formamide Ambient temperature;
参考文献
Testaferri, Lorenzo; Tiecco, Marcello; Tingoli, Marco; Bartoli, Donatella; Massoli, Alberto
Tetrahedron, 1985 , vol. 41, # 7 p. 1373 - 1384
反应条件
1.1: diethyl ether / 0 °C / |Inert atmosphere 2.1: lithium diisopropyl amide / diethyl ether / -78 °C / |Inert atmosphere 2.2: -78 °C / |Inert atmosphere View Scheme
参考文献
Dhau, Jaspreet S.; Singh, Amritpal; Kasetti, Yoganjaneyulu; Bhatia, Sonam; Bharatam, Parsad V.; Brandao, Paula; Felix, Vitor; Singh, Kamal N.
Tetrahedron, 2013 , vol. 69, # 48 p. 10284 - 10291
反应条件
1: water; isopropyl alcohol; ethyl acetate 2: potassium acetate View Scheme
参考文献
Xuanzhu Pharma Co., Ltd.; WU, Frank; ZHANG, Yan
Patent: EP2719697 A1, 2014 ;
反应条件
1: With n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran; hexanes; toluene T=-40 - 20°C; 1 h; 2: With hydrogenchloride in tetrahydrofuran; hexanes; water; toluene T=20°C; 3: With sodium hydroxide in tetrahydrofuran; hexanes; water; ethyl acetate; toluene pH=7;
参考文献
METHYLGENE INC.
Patent: WO2005/92899 A1, 2005 ;
Location in patent: Page/Page column 79-80 ;
反应条件
nitrogen; potassium acetate; triethylamine; palladium in hexane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate
参考文献
X-Ceptor Therapeutics, Inc.
Patent: US2005/80111 A1, 2005 ;
US 20050080111 A1
参考文献
Xuanzhu Pharma Co., Ltd.; Wu, Frank; Zhang, Yan
Patent: US2014/93505 A1, 2014 ;
Location in patent: Page/Page column ;
