2,4-二氯-5-嘧啶甲酸乙酯合成路线 （共 16 条）
反应条件
N,N-diethylaniline; trichlorophosphate 2 h; Heating / reflux;
参考文献
LU, Pu-Ping; CHUANG, Chihyuan Grace; MORGAN, Bradley P.; MORGANS, JR., David J.
Patent: US2009/198057 A1, 2009 ;
Location in patent: Page/Page column 18 ;
反应条件
in tetrahydrofuran T=20°C; 0.166667 h;
参考文献
SANOFI-AVENTIS
Patent: US2011/251194 A1, 2011 ;
Location in patent: Page/Page column 22 ;
反应条件
N,N-diethylaniline; trichlorophosphate T=105°C;
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
Location in patent: Paragraph 00569 ;
WO 2013/043232 A2
反应条件
in sulfuryl dichloride
参考文献
Yamada, Koichiro; Matsuki, Kenji; Omori, Kenji; Kikkawa, Kohei
Patent: US2003/32647 A1, 2003 ;
反应条件
1: sodium ethanolate / ethanol / 48 h / 20 - 90 °C 2: trichlorophosphate; N,N-dimethyl-aniline / benzene / 8 h / 90 °C / Inert atmosphere View Scheme
参考文献
Pawar; Burungale; Karale
Indian Journal of Heterocyclic Chemistry, 2010 , vol. 20, # 2 p. 133 - 136
反应条件
1: phosphorus pentachloride; trichlorophosphate / 16 h / 0 °C / Inert atmosphere; Reflux 2: tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere View Scheme
参考文献
SANOFI-AVENTIS
Patent: US2011/251194 A1, 2011 ;
反应条件
1.1: pyridine; thionyl chloride / 16 h / 15 - 75 °C 1.2: 16 h / |Reflux 2.1: trichlorophosphate; N,N-diethylaniline / 105 °C View Scheme
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
WO 2013/043232 A2
反应条件
sodium hydroxide; palladium on activated charcoal; diethyl ether Hydrogenation.anschliessendes Erhitzen mit;
参考文献
Smith; Christensen
Journal of Organic Chemistry, 1955 , vol. 20, p. 829,833,835
反应条件
anschliessendes Erhitzen.Hydrogenation;
参考文献
Smith; Christensen
Journal of Organic Chemistry, 1955 , vol. 20, p. 829,833,835
反应条件
in methanol T=20°C; 2 h; Overall yield = 12 g;
参考文献
MERCK SHARP and DOHME CORP.; ARRINGTON, Kenneth, L.; BURGEY, Christopher; GILFILLAN, Robert; HAN, Yongxin; PATEL, Mehul; LI, Chun Sing; LI, Yaozong; LUO, Yunfu; LEI, Zhiyu; XU, Jiayi
Patent: WO2014/58747 A1, 2014 ;
Location in patent: Page/Page column 191 ;
