螺[嘧啶-5,1'-环己烷]-2,4,6(1H,3H,5H)-三酮合成路线 （共 17 条）
反应条件
bis(1,5-cyclooctadiene)nickel (0); triethylsilyl trifluoromethanesulphonate; triethylamine; diphenylcyclohexyl phosphine in toluene
T=20°C; Heck type reaction; P=760.051 Torr; 2 h;
参考文献
Matsubara, Ryosuke; Gutierrez, Alicia C.; Jamison, Timothy F.
Journal of the American Chemical Society, 2011 , vol. 133, # 47 p. 19020 - 19023
反应条件
sodium methylate
3 h;
参考文献
Gosselin, Gilles; Bergogne, Marie-Chistine; Rudder, Jean de; Clercq, Erik De; Imbach, Jean-Louis
Journal of Medicinal Chemistry, 1986 , vol. 29, # 2 p. 203 - 213
反应条件
palladium diacetate; triphenylphosphine-3,3',3''-trisulfonic acid trisodium salt; triethylamine T=130°C; Heck reaction, debromiation; 8 h;
参考文献
Tetrahedron Letters, , vol. 40, # 44 p. 7803 - 7806
反应条件
Stage #1: With potassium hydroxide; water in 1,4-dioxane T=20°C; 1.5 h; Stage #2: With water; acetic acid T=80°C; 3 h; Further stages.;
参考文献
Yokoyama, Yuusaku; Hikawa, Hidemasa; Mitsuhashi, Masaharu; Uyama, Aki; Hiroki, Yasuhiro; Murakami, Yasuoki European Journal of Organic Chemistry, 2004 , # 6 p. 1244 - 1253
反应条件
Stage #1: With potassium hydroxide; water in 1,4-dioxane T=20°C; 1.5 h; Stage #2: With water; acetic acid T=80°C; 3 h; Further stages.;
参考文献
Yokoyama, Yuusaku; Hikawa, Hidemasa; Mitsuhashi, Masaharu; Uyama, Aki; Hiroki, Yasuhiro; Murakami, Yasuoki European Journal of Organic Chemistry, 2004 , # 6 p. 1244 - 1253
反应条件
1: 5.2 g / 20percent oleum / 5 h / 60 - 65 °C
2: 72 percent Chromat. / PCl5 / 7 h / 170 °C
View Scheme
参考文献
Karpov, V. M.; Platonov, V. E.; Chuikov, I. P.; Yakobson, G. G.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, # 10 p. 1880 - 1888
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 10 p. 2164 - 2173
反应条件
cesium fluoride
T=200 - 235°C; 8 h;
参考文献
Karpov, V. M.; Platonov, V. E.; Chuikov, I. P.; Yakobson, G. G.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, # 10 p. 1880 - 1888
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 10 p. 2164 - 2173
反应条件
bromine
T=20°C; 1 h;
参考文献
Karpov, V. M.; Platonov, V. E.; Chuikov, I. P.; Yakobson, G. G.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, # 10 p. 1880 - 1888
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 10 p. 2164 - 2173
反应条件
hydrogenchloride; bromine; zinc
1.) dioxane, 100 deg C, 2.) 20 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Karpov, V. M.; Platonov, V. E.; Chuikov, I. P.; Yakobson, G. G.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, # 10 p. 1880 - 1888
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 10 p. 2164 - 2173
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane
T=20°C; 1 h;
参考文献
Wang, Ying; Sarris, Kathy; Sauer, Daryl R.; Djuric, Stevan W.
Tetrahedron Letters, 2007 , vol. 48, # 30 p. 5181 - 5184
