4-甲氧基-2-甲基苄醇合成路线 （共 17 条）
反应条件
1: 97 percent / potassium carbonate / acetone / 19 h / Heating
2: 100 percent / LiAlH4, Celite / tetrahydrofuran / 2 h / 0 - 20 °C
View Scheme
参考文献
Shishido; Yamashita; Hiroya; Fukumoto; Kametani
Tetrahedron, 1989 , vol. 45, # 18 p. 5791 - 5804
反应条件
air; Titanium(IV) oxide; silver sulphate in water; acetonitrile
Oxidation; oxygenation; 2 h; Irradiation;
参考文献
Ranchella, Michele; Rol, Cesare; Sebastiani, Giovanni V.
Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 2 p. 311 - 315
反应条件
lithium aluminium tetrahydride in diethyl ether
Reduction; deacetylation;
参考文献
Ranchella, Michele; Rol, Cesare; Sebastiani, Giovanni V.
Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 2 p. 311 - 315
反应条件
1.1: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C
2.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 1.33 h / 0 - 20 °C
2.2: 0 °C
View Scheme
参考文献
ARAGON PHARMACEUTICALS, INC.; KAHRAMAN, Mehmet; GOVEK, Steven, P.; NAGASAWA, Johnny, Y.; SMITH, Nicholas, D.
Patent: WO2011/156518 A2, 2011 ;
WO 2011/156518 A2
反应条件
1: With N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane
Bromination; oxidation; 2 h; Heating;
2: With sodium hydroxide in water; acetone
Hydrolysis; Further stages.;
参考文献
Ranchella, Michele; Rol, Cesare; Sebastiani, Giovanni V.
Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 2 p. 311 - 315
反应条件
1: HCl; ZnCl2; petroleum ether / 0 - 5 °C
2: sodium acetate / auf dem Dampfbad und Kochen des Reaktionsprodukts mit wss.-aethanol. KOH
View Scheme
参考文献
Quelet et al.
Bulletin de la Societe Chimique de France, 1937 , vol. <5> 4, p. 1092,1095
反应条件
sodium acetate
auf dem Dampfbad und Kochen des Reaktionsprodukts mit wss.-aethanol. KOH;
参考文献
Quelet; Allard
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1937 , vol. 204, p. 130
Full Text Show Details
Quelet et al.
Bulletin de la Societe Chimique de France, 1937 , vol. <5> 4, p. 1092,1095
