2-氯-6-甲基吡啶 1-氧化物合成路线 (共 13 条)
反应条件
1: H2SO4 / 20 - 110 °C 2: 815 mg / K2CO3 / methanol; H2O / 0.25 h / 20 °C View Scheme
参考文献
Iqbal, Nadeem; Akula, Murthy R.; Vo, Dean; Matowe, Wandikayi C.; McEwen, Carol-Anne; Wolowyk, Michael W.; Knaus, Edward E.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1827 - 1837
反应条件
hydrogenchloride; acetic anhydride 1.) 120-130 deg C, 2.5 h, 2.) reflux, 2 h; Yield given. Multistep reaction;
参考文献
Haviv, Fortuna; DeNet, Robert W.; Michaels, Raymond J.; Ratajczyk, James D.; Carter, George W.; Young, Patrick R.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 218 - 222
反应条件
triethylamine in dichloromethane; trichlorophosphate
参考文献
Union Carbide Corporation
Patent: US4576629 A1, 1986 ;
反应条件
methanesulfonyl chloride in 1,4-dioxane 16 h; Heating;
参考文献
Barnes, John H.; Hartley, Frank R.; Jones, Christopher E. L.
Tetrahedron, 1982 , vol. 38, # 22 p. 3277 - 3280
反应条件
1: 77 percent / 1 h / Heating 2: 51 percent / K2CO3 / methanol / 25 °C 3: 52 percent / MnO2 / CHCl3 / 24 h / 25 °C View Scheme
参考文献
Iqbal, Nadeem; Akula, Murthy R.; Vo, Dean; Matowe, Wandikayi C.; McEwen, Carol-Anne; Wolowyk, Michael W.; Knaus, Edward E.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1827 - 1837
参考文献
Kureha Kagaku Kogyo K.K.
Patent: US6610853 B1, 2003 ;
反应条件
3-chloro-benzenecarboperoxoic acid in chloroform
T=50°C; Oxidation; 12 h;
参考文献
Lee; Choi; Choe; Kim; Chi
Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # SUPPL. 1 p. S99-S101
Title/Abstract Full Text View citing articles Show Details
Lee, Kyo Chul; Chi, Dae Yoon
Journal of Organic Chemistry, 1999 , vol. 64, # 23 p. 8576 - 8581
反应条件
in tetrahydrofuran; cyclohexanone
参考文献
Abbott Laboratories
Patent: US5288743 A1, 1994 ;
US 5288743 A
参考文献
Schaper; Klaus-Jurgen; Seydel; Joachim K.
Patent: US4997835 A1, 1991 ;
反应条件
hydrogenchloride; sodium nitrite
Erhitzen der Reaktionsloesung unter Durchleiten von Wasserdampf und Erwaermen des Reaktionsprodukts mit Peroxyessigsaeure in Essigsaeure;
参考文献
Brown
Journal of the American Chemical Society, 1957 , vol. 79, p. 3565