2-氯-5-三氟甲基吡啶合成路线 （共 80 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=60 - 90°C; 4 h;
参考文献
Shenyang Research Institute Of Chemical Industry Co., Ltd.; SINOCHEM CORPORATION; Liu, Changling; Yang, Jichun; Chang, Xiuhui; Li, Miao; Li, KeKe; Wu, Qiao; Song, Yuquan
Patent: US2013/303541 A1, 2013 ;
Location in patent: Paragraph 0089 ;
反应条件
sodium hydroxide; hydroquinone in diethyl ether; water
参考文献
Ishihara Sangyo Kaisha, Ltd.
Patent: US4216007 A1, 1980 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=110 - 120°C; 4 h;
参考文献
Watson, Keith G.; Serban, Alexander
Australian Journal of Chemistry, 1995 , vol. 48, # 8 p. 1503 - 1510
反应条件
potassium hydroxide; pyridine hydrochloride; dimethyl sulfoxide
参考文献
Ishihara Sangyo Kaisha Ltd.
Patent: US4152328 A1, 1979 ;
反应条件
Yield given. Multistep reaction;
参考文献
Watson, Keith G.; Serban, Alexander
Australian Journal of Chemistry, 1995 , vol. 48, # 8 p. 1503 - 1510
反应条件
aluminum oxide; potassium fluoride in N,N-dimethyl-formamide
T=120°C; 5 h;
参考文献
Hwang, Ki-Jun; Park, Seung Ki
Synthetic Communications, 1990 , vol. 20, # 7 p. 949 - 954
反应条件
potassium carbonate in water; toluene
0.5 h; microwave irradiation;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/73934 A1, 2007 ;
Location in patent: Page/Page column 72-73 ;
反应条件
1: 2-hydroxyisobutyric acid ethyl ester With potassium hexamethylsilazane in tetrahydrofuran
T=-70 - -62°C; 0.666667 h;
2: 2-chloro-5-(trifluoromethyl)-pyridine in tetrahydrofuran
T=-62 - 20°C; 16 h;
参考文献
MERCK and CO., INC.
Patent: WO2007/136571 A1, 2007 ;
Location in patent: Page/Page column 44-45 ;
WO 2007/136571 A1
参考文献
Auerbach, Bruce J.; Bratton, Larry D.; Filzen, Gary F.; Geyer, Andrew G.; Trivedi, Bharat K.; Unangst, Paul C.
Patent: US2003/225158 A1, 2003 ;
Location in patent: Page 54 - 55 ;
反应条件
1: Et3N; CuI; Pd(Ph3P)2Cl2 / tetrahydrofuran / 3 h / Heating
2: aq. KOH / methanol; CHCl3 / 0.5 h / 20 °C
View Scheme
参考文献
Yamaguchi, Yoshihiro; Tanaka, Takahiro; Kobayashi, Shigeya; Wakamiya, Tateaki; Matsubara, Yoshio; Yoshida, Zen-Ichi
Journal of the American Chemical Society, 2005 , vol. 127, # 26 p. 9332 - 9333
