反应条件
1: 1.) t-BuNH2, Br2, 2.) 4-(dimethylamino)pyridine / 1.) toluene, CH2Cl2, -78 to RT, 5 h, 2.) pyridine, room temp., 24 h
2: 95 percent / n-BuLi / tetrahydrofuran / 10 h / -78 - 20 °C
3: 54 percent / conc. HCl / methanol / 3 h / Heating
5: 72 percent / n-BuLi / tetrahydrofuran; hexane / 7 h / -78 - 20 °C
6: 88 percent / NaI, trimethylsilyl chloride / acetonitrile / 3 h / Ambient temperature
View Scheme
参考文献
Jung; Koreeda
Journal of Organic Chemistry, 1989 , vol. 54, # 24 p. 5667 - 5675
