反应条件
1: 1.) AlCl3, Br2, 2.) NaBH4 / 1.) CH2Cl2, 40 deg.C, 30 min, 2.) CH3OH, 0 deg.C, 2 h 2: 75 percent / 1.) NaH / dimethylformamide / 1.) 0 deg.C, 30 min, 2.) 30 deg.C, 3 h 3: 1.) Mg / 1.) THF, reflux, 2.5 h, 2.) THF, reflux 3 h 4: 82 percent / pyridinium chlorochromate / CH2Cl2 / 36 h / 25 °C 5: 90 percent / tetrahydrofuran / 1.) -78 deg. C, 1 h, 2.) -78 - 0 deg.C, 1 h 6: 100 percent / phosphoryl chloride / CH2Cl2 / 1 h / 25 °C 7: 91 percent / H2 / 10percent Pd/C / ethyl acetate / 48 h / 3102.9 Torr 8: 68 percent / DDQ / CH2Cl2 / 1 h View Scheme
参考文献
Stoilov; Watt; Goodman; St. Pyrek
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 6 p. 1645 - 1652
