甲基2-乙基-2-甲基丁酸酯合成路线 （共 16 条）
反应条件
1: hexane; carbon monoxide With aluminum tri-bromide; carbon tetrabromide in various solvent(s)
2: methanol in various solvent(s)
Title compound not separated from byproducts;
参考文献
Akhrem, Irena S.; Afanas'eva, Lyudmila V.; Vitt, Sergei V.; Petrovskii, Pavel V.
Mendeleev Communications, 2002 , vol. 12, # 5 p. 180 - 182
参考文献
Sarel; Newman
Journal of the American Chemical Society, 1956 , vol. 78, p. 5416,5418
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Sarel; Newman
Journal of the American Chemical Society, 1956 , vol. 78, p. 5416,5418
反应条件
1: 1.) LDA / 1.) THF, -78 deg C, 0.5 h, 2.) THF, a) -78 deg C, 0.5 h, b) from -78 deg C to RT, 2 h, c) RT, 13 h
2: NH2OH*HCl, aq. NaOH / ethanol / 1.5 h / Heating
View Scheme
参考文献
Rouchaud, J.; Gustin, F.; Moulard, C.
Bulletin des Societes Chimiques Belges, 1993 , vol. 102, # 8 p. 545 - 556
反应条件
lithium diisopropyl amide in tetrahydrofuran
1.) -78 deg C, 1 h, 2.) RT, 13 h;
参考文献
Rouchaud, J.; Gustin, F.; Moulard, C.
Bulletin des Societes Chimiques Belges, 1993 , vol. 102, # 8 p. 545 - 556
反应条件
1: sodium hydroxide / methanol / 60 °C
2: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 17 h / 0 - 20 °C
View Scheme
参考文献
Wu, Xuesong; Zhao, Yan; Zhang, Guangwu; Ge, Haibo
Angewandte Chemie - International Edition, 2014 , vol. 53, # 14 p. 3706 - 3710
Angew.Chem.Int.Ed., 2014 , vol. 126, # 14 p. 3780 - 3794,5
