4,6-二氯-5-嘧啶甲醛合成路线 （共 55 条）
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=0°C; 1 h; 2: 4,6-dihydroxy-pyrimidine T=20°C; 0.5 h;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2006/135719 A1, 2006 ;
Location in patent: Page/Page column 46-47 ;
WO 2006/135719 A1
反应条件
trichlorophosphate T=0 - 20°C; Vilsmeier Formylation; 4.5 h; Heating / reflux;
参考文献
Gaul, Michael David; Xu, Guozhang; Baumann, Christian Andrew
Patent: US2006/281764 A1, 2006 ;
Location in patent: Page/Page column 25 ;
US 20060281764 A1
反应条件
trichlorophosphate in DMF (N,N-dimethyl-formamide) T=0 - 90°C; 6.5 h;
参考文献
Wittman, Mark D.; Balasubramanian, Neelakantan; Velaparthi, Upender; Zimmermann, Kurt; Saulnier, Mark G.; Liu, Peiying; Sang, Xiaopeng; Frennesson, David B.; Stoffan, Karen M.; Tarrant, James G.; Marinier, Anne; Roy, Stephan
Patent: US2004/44203 A1, 2004 ;
Location in patent: Page 30 ;
US 20040044203 A1
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=0°C; 1 h; 2: 4,6-dichloro-pyrimidine T=120°C; 3 h;
参考文献
BAYER HEALTHCARE AG
Patent: WO2004/43926 A1, 2004 ;
Location in patent: Page 140 ;
WO 2004/043926 A1
反应条件
triethylamine in tetrahydrofuran T=65°C; 1 h;
参考文献
Organic Letters, , vol. 15, # 8 p. 1882 - 1885
反应条件
triethylamine in tetrahydrofuran T=20 - 65°C; 1 h; Reactivity; Reagent/catalystSolvent;
参考文献
Tetrahedron Letters, , vol. 49, # 52 p. 7395 - 7397
反应条件
acetic acid in 1,4-dioxane
参考文献
Ryabova; Evstratova; Makarov; Tafeenko; Granik
Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 10 p. 1352 - 1358
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 12 p. 3495 - 3499
反应条件
1: N,N-dimethyl-formamide / 1 h / 20 °C / |Inert atmosphere 2: 1,4-dioxane / 0.33 h / 200 °C / |Sealed tube View Scheme
参考文献
Morrill, Christie; Babu, Suresh; Almstead, Neilg.; Moon, Young-Choon
Synthesis (Germany), 2013 , vol. 45, # 13 art. no. SS-2013-C0248-OP, p. 1791 - 1806
反应条件
triethylamine; hydrazine in 1,4-dioxane T=20°C; 1 h;
参考文献
Sunesis Pharmaceuticals, Inc
Patent: US2009/5359 A1, 2009 ;
Location in patent: Page/Page column 18 ;
US 20090005359 A1
