2-硝基-1,4-苯二胺合成路线 （共 41 条）
反应条件
1: isopropyl alcohol / 75 °C 2: sodium hydroxide; sodium tetrahydroborate / 75 °C 3: sodium ethanolate / 1.5 h / 20 - 25 °C View Scheme
参考文献
Adams et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 1114,1117
反应条件
2: acetic acid; water; iron View Scheme
参考文献
Buelow; Mann
Chemische Berichte, 1897 , vol. 30, p. 986
参考文献
McFarlane, Michael D.; Moody, David J.; Smith, David M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 691 - 696
反应条件
rat liver cytosol protein; [14C]-Acetyl-Coenzyme A T=37°C; 0.5 h; solvent: propylene glycol, Tris-HCl buffer (pH 7.5); var. arylamines, var. nitroanilines; in vitro metabolism study; Product distribution;
参考文献
Buelow; Mann
Chemische Berichte, 1897 , vol. 30, p. 986
参考文献
Boulton,A.J. et al.
Journal of the Chemical Society [Section] C: Organic, 1966 , p. 971 - 976
参考文献
Buelow; Mann
Chemische Berichte, 1897 , vol. 30, p. 986
反应条件
water; sodium hydroxide T=100°C; 4 h;
参考文献
Imoto, Mitsutaka; Matsui, Yasunori; Takeda, Motonori; Tamaki, Akihiro; Taniguchi, Hisaji; Mizuno, Kazuhiko; Ikeda, Hiroshi
Journal of Organic Chemistry, 2011 , vol. 76, # 15 p. 6356 - 6361
反应条件
in anhydrous xylene; water
参考文献
Asta Medica Aktiengesellschaft
Patent: US5384330 A1, 1995 ;
反应条件
1: isopropyl alcohol / 75 °C 2: sodium hydroxide; sodium tetrahydroborate / 75 °C 3: sodium ethanolate / 1.5 h / 20 - 25 °C 4: hydrogen / 1 Pt, 2 vanadium on carbon / ethanol / 3 h / 50 - 70 °C / 1500.15 Torr / Inert atmosphere; Industry scale View Scheme
参考文献
GLAXO GROUP LIMITED; FITZGERALD, Russ, N; MILLAR, Alan; TOCZKO, Jennifer, Fell
Patent: WO2012/98075 A1, 2012 ;
