反应条件
1: 76 percent / Dess-Martin periodinane, pyridine / CH2Cl2 / 2 h / Ambient temperature; 1.) 0 deg C to room temperature, 3 h, 2.) room temperature, 16 h 2: 80 percent / aq. HF / acetonitrile / 4 h / Ambient temperature 3: 99 percent / 2,6-lutidine, Et3N / CH2Cl2 / 5 h / -78 °C 4: 1.) Bu3SnH, AIBN, 2.) I2 / 1.) benzene, 90 deg C, 1 h, 2.) CH2Cl2, 0 deg C 5: 56 percent / LiI / pyridine / 16 h / 130 °C 6: 1.) EDS, DMAP, DMAP*HCl, 2.) i-Pr2NEt, <(2-furyl)3P>2PdCl2 / 1.) CH2Cl2, room temperature, 5 h, 2.) THF, DMF, room temperature, 7 h 7: 90 percent / TBAF, AcOH / tetrahydrofuran / 3 h / 0 °C 8: 71 percent / HF*pyr, pyridine / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Journal of the American Chemical Society, , vol. 119, # 5 p. 962 - 973
