2-乙酰氨基-6-甲基嘧啶合成路线 （共 34 条）
反应条件
N-bromosuccinmide; perchloric acid; dibenzoyl peroxide in tetrachloromethane 5 h; Heatingirradiation;
参考文献
Goswami; Ghosh; Mukherjee; Avijit Kumar Adak; Ajit Kumar Mahapatra
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 1 p. 173 - 178
反应条件
1: acetic acid 2: aqueous NaOH View Scheme
参考文献
Adams; Miyano
Journal of the American Chemical Society, 1954 , vol. 76, p. 2785
反应条件
sodium hydroxide T=70°C; 1 h; Yield given;
参考文献
Vijn, Robert J.; Arts, Henricus J.; Maas, Peter J.; Castelijns, Anna M.
Journal of Organic Chemistry, 1993 , vol. 58, # 4 p. 887 - 891
反应条件
1: 54.7 percent / aq. KMnO4 / 2 h / 75 °C 2: 88 percent / 10percent aq. NaOH / 2 h / Heating 3: 54.5 percent / HCl / 9 h / Heating View Scheme
参考文献
Ferrari; Marcon
Farmaco, Edizione Scientifica, 1959 , vol. 14, p. 594,596
反应条件
1: 73 percent 2: N-bromosuccinimide / CCl4 / 19 h / Heating 3: 32 percent / silver nitrate / ethanol; H2O / 0.25 h / Heating View Scheme
参考文献
Abarca; Asensio; Jones; Mouat
Tetrahedron, 1989 , vol. 45, # 22 p. 7041 - 7048
反应条件
1: 73 percent 2: N-bromosuccinimide / CCl4 / 19 h / Heating 3: 32 percent / silver nitrate / ethanol; H2O / 0.25 h / Heating 4: 55.5 percent / methanol 5: 1.) morpholine; 2.) sodium hydroxide / 1.) 95 deg C, 1 h; 2.) 60 deg C, 2 h View Scheme
参考文献
Abarca; Asensio; Jones; Mouat
Tetrahedron, 1989 , vol. 45, # 22 p. 7041 - 7048
反应条件
1: 54.7 percent / aq. KMnO4 / 2 h / 75 °C 2: 88 percent / 10percent aq. NaOH / 2 h / Heating 3: 54.5 percent / HCl / 9 h / Heating 4: 100 percent / Et3N / CHCl3 / 5 h / Ambient temperature 5: 84.5 percent / DIBAL / toluene / 0.5 h / -70 °C 6: 83.8 percent / piperidine / benzene / 22 h / Heating 7: 99.5 percent / H2 / Pd / tetrahydrofuran; methanol / 5 h / 760 Torr / Ambient temperature 8: 50percent aq. NaOH / 2 h / Heating 9: benzene / 2 h / Heating 10: 96.6 percent / 50percent aq. AcOH / 0.5 h / Heating View Scheme
参考文献
Fukase, Koichi; Nakayama, Hideo; Kurosawa, Motohiro; Ikegaki, Toshiki; Kanoh, Takeshi; et al.
Journal of Carbohydrate Chemistry, 1994 , vol. 13, # 5 p. 715 - 736
反应条件
1: N-(6-methyl-pyridin-2-yl)acetamide With potassium permanganate in water T=75°C; 2: methanol With hydrogenchloride; water 24 h; Reflux; 3: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2098513 A1, 2009 ;
Location in patent: Page/Page column 48 ;
EP 2098513 A1
反应条件
1: 16.5 g / KMnO4 / H2O / 3 h / 75 °C 2: HCl / Heating View Scheme
参考文献
Baumann, Karlheinz; Goetschi, Erwin; Green, Luke; Jolidon, Synese; Knust, Henner; Limberg, Anja; Luebbers, Thomas; Thomas, Andrew
Patent: US2011/190269 A1, 2011 ;
反应条件
N-bromosuccinmide; dibenzoyl peroxide in water 1 h; Irradiation;
参考文献
Goswami; Ghosh; Mukherjee; Avijit Kumar Adak; Ajit Kumar Mahapatra
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 1 p. 173 - 178
