4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide T=20°C; 3 h;

1: 60 percent / dimethylformamide / 20 h / 130 °C 2: 74 percent / KOH / ethanol / Heating 3: 75 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; p-dimethylaminopyridine / dimethylformamide / 3 h / 20 °C View Scheme

1: 74 percent / KOH / ethanol / Heating 2: 75 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; p-dimethylaminopyridine / dimethylformamide / 3 h / 20 °C View Scheme