N-(2-氯苯基)乙酰胺合成路线 （共 129 条）
参考文献
Jackson,F.H.; Peters,A.T.
Journal of the Chemical Society [Section] C: Organic, 1969 , p. 268 - 272
反应条件
nitric acid; acetic anhydride; acetic acid
Behandeln des Reaktionsprodukts mit wss.-aethanol.Kalilauge;
参考文献
van Duin
Recueil des Travaux Chimiques des Pays-Bas, 1932 , vol. 51, p. 878,879
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Wepster; Verkade
Recueil des Travaux Chimiques des Pays-Bas, 1949 , vol. 68, p. 88,89
参考文献
Lobry de Bruyn
Recueil des Travaux Chimiques des Pays-Bas, 1917 , vol. 36, p. 139
反应条件
T=-5°C; und Behandeln des danach isolierten Reaktionsprodukts mit wss.-aethanol. Kalilauge;
参考文献
Wepster; Verkade
Recueil des Travaux Chimiques des Pays-Bas, 1949 , vol. 68, p. 88,89
反应条件
1: N-(2-chlorophenyl)-acetamide With sodium hydride in tetrahydrofuran
T=0°C; 0.5 h; Inert atmosphere;
2: methyl iodide in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
参考文献
Zhu, Manghong; Zhang, Chen; Nwachukwu, Jerome C.; Srinivasan, Sathish; Cavett, Valerie; Zheng, Yangfan; Carlson, Kathryn E.; Dong, Chune; Katzenellenbogen, John A.; Nettles, Kendall W.; Zhou, Hai-Bing
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 43 p. 8692 - 8700
参考文献
Goehring, R. Richard; Sachdeva, Yesh P.; Pisipati, Jyothi S.; Sleevi, Mark C.; Wolfe, James F.
Journal of the American Chemical Society, 1985 , vol. 107, # 2 p. 435 - 443
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate
1.) toluene, 30-35 deg C, 30 min, 2.) toluene, 30-35 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Kalkote; Choudhary; Natu; Lahoti; Ayyangar
Synthetic Communications, 1991 , vol. 21, # 18-19 p. 1889 - 1900
反应条件
pyridine
4 h; Heating;
参考文献
Ayyangar, Nagaraj R.; Srinivasan, Kumar V.
Canadian Journal of Chemistry, 1984 , vol. 62, p. 1292 - 1296
反应条件
1: chlorosulfonic acid / 3.5 h / 70 - 80 °C
2: aq. NH4OH / 0.5 h / 70 °C
View Scheme
参考文献
Ilies, Marc A.; Vullo, Daniela; Pastorek, Jaromir; Scozzafava, Andrea; Ilies, Monica; Caproiu, Miron T.; Pastorekova, Silvia; Supuran, Claudiu T.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2187 - 2196
反应条件
1,1'-bis-(di-tert-butylphosphino)ferrocene; potassium carbonate; palladium diacetate in 1-methyl-pyrrolidin-2-one
T=110°C;
参考文献
Shen, Ming; Li, Guisheng; Lu, Bruce Z.; Hossain, Azad; Roschangar, Frank; Farina, Vittorio; Senanayake, Chris H.
Organic Letters, 2004 , vol. 6, # 22 p. 4129 - 4132
