2-(苯基甲基)-肼羧酸 1,1-二甲基乙酯合成路线 （共 18 条）
反应条件
1: aq. HCl
2: benzene; 2-methyl-propan-2-ol
View Scheme
参考文献
Baumgarten,H.E. et al.
Journal of Organic Chemistry, 1976 , vol. 41, p. 3805 - 3811
反应条件
1: 4-methyl-morpholine / dichloromethane / 0 - 20 °C
2: 4-methyl-morpholine / dichloromethane / 18 h / 10 - 20 °C
View Scheme
参考文献
Baburaj, Thankappan; Thambidurai, Sivalingam
Synlett, 2011 , # 14 art. no. B08111ST, p. 1993 - 1996
反应条件
1: dimethyl sulfoxide; triethylamine; sulfur trioxide pyridine complex / dichloromethane; methanol / 0 °C
2: acetic acid / methanol
3: acetic acid; sodium cyanoborohydride; methanol / 3 h
View Scheme
参考文献
Clavette, Christian; Vincent Rocan, Jean-Francois; Beauchemin, Andre M.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 48 p. 12705 - 12708
Angew. Chem., 2013 , vol. 125, # 48 p. 12937 - 12940,4
反应条件
in tert-butyl alcohol; benzene
参考文献
Baumgarten,H.E. et al.
Journal of Organic Chemistry, 1976 , vol. 41, p. 3805 - 3811
反应条件
in tetrahydrofuran; methanol
参考文献
Abbott Laboratories
Patent: US5461067 A1, 1995 ;
US 5461067 A
参考文献
Sham, Hing L.; Betebenner, David A.; Zhao, Chen; Wideburg, Norman E.; Saldivar, Ayda; et al.
Journal of the Chemical Society, Chemical Communications, 1993 , # 13 p. 1052 - 1053
反应条件
1: aq. NaOH / CHCl3
2: aq. HCl / ethyl acetate
View Scheme
参考文献
Dutta; Morley
Journal of the Chemical Society. Perkin transactions 1, 1975 , # 17 p. 1712 - 1720
反应条件
triethylamine in ethyl acetate
T=0°C;
参考文献
Wieczerzak; Kozlowska; Lankiewicz; Grzonka
Polish Journal of Chemistry, 2002 , vol. 76, # 12 p. 1693 - 1697
