(R)-(-)-六氢扁桃酸合成路线 （共 10 条）
反应条件
rhodium contaminated with carbon; hydrogen; acetic acid in methanol T=20°C; P=72402.6 Torr; 8 h;
参考文献
Board of Trustees of Michigan State University
Patent: US2007/142461 A1, 2007 ;
Location in patent: Page/Page column 6 ;
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran; water T=0°C; Hydrolysis; 1 h;
参考文献
Aggarwal, Varinder K.; Thomas, Abraham; Schade, Steffen
Tetrahedron, 1997 , vol. 53, # 48 p. 16213 - 16228
反应条件
potassium hydroxide; water 8 h; Ambient temperature;
参考文献
Tsuboi, Sadao; Nishiyama, Emiko; Utaka, Masanori; Takeda, Akira
Tetrahedron Letters, 1986 , vol. 27, # 17 p. 1915 - 1916
反应条件
hydrogenchloride 1a) r.t., 18 h, 1b) 60 deg C, 3 h, 1c) reflux, 2 h;
参考文献
Ziegler, Thomas; Hoersch, Brigitte; Effenberger, Franz
Synthesis, 1990 , # 7 p. 575 - 578
反应条件
dipyridinium dichromate in dichloromethane T=25°C; 2 h;
参考文献
Tetrahedron Asymmetry, , vol. 13, # 1 p. 29 - 36
反应条件
1: 78 percent / HCl, Zn / diethyl ether / 2 h / -5 °C 2: 59 percent / KOH, H2O / 8 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 7 p. 1359 - 1362
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.58 h / -78 °C 1.2: 63 percent / tetrahydrofuran; hexane / 1 h / -100 °C 2.1: 75 percent / mercuric acetate; aqueous acetic acid; calcium carbonate / 80 °C / pH 7 3.1: pyridinium dichromate / CH2Cl2 / 2 h / 25 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 13, # 1 p. 29 - 36
反应条件
1: sodium borohydride / methanol; H2O / 1 h / 25 °C 2: 75 percent / mercuric acetate; aqueous acetic acid; calcium carbonate / 80 °C / pH 7 3: pyridinium dichromate / CH2Cl2 / 2 h / 25 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 13, # 1 p. 29 - 36
反应条件
1: 75 percent / mercuric acetate; aqueous acetic acid; calcium carbonate / 80 °C / pH 7 2: pyridinium dichromate / CH2Cl2 / 2 h / 25 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 13, # 1 p. 29 - 36
反应条件
1: 96 percent / PPTS / ethanol / 10 h / 70 °C 2: 90 percent / aq. H2O2; lithium hydroxide monohydrate / H2O; tetrahydrofuran / 1 h / 0 °C View Scheme
参考文献
Tetrahedron, , vol. 53, # 48 p. 16213 - 16228
