Leardini, Rino; Pedulli, Gian Franco; Tundo, Antonio; Zanardi, Giuseppe
Journal of the Chemical Society, Chemical Communications, 1984 , # 20 p. 1320 - 1321
1: 4-chloro-benzoyl chloride; phenylacetylene With copper(l) iodide; Pd2(PPh3)2Cl2; triethylamine in tetrahydrofuran
T=20°C; Sonogashira coupling-Michael addition-cyclocondensation-sulfur extrusion; 1 h; Inert atmosphereCombinatorial reaction / High throughput screening (HTS);
2: 2-amino-benzenethiol With acetic acid in tetrahydrofuran; isopropyl alcohol
T=150°C; Sonogashira coupling-Michael addition-cyclocondensation-sulfur extrusion; 1 h; Microwave irradiationInert atmosphereCombinatorial reaction / High throughput screening (HTS); regiospecific reaction;
参考文献
Rotzoll, Sven; Willy, Benjamin; Schoenhaber, Jan; Rominger, Frank; Mueller, Thomas J. J.
European Journal of Organic Chemistry, 2010 , # 18 p. 3516 - 3524
1: phenylacetylene With n-butyllithium in tetrahydrofuran; hexane
T=0°C;
2: With zinc dibromide in tetrahydrofuran; hexane
T=0°C;
3: pyridine-3-carbonitrile With n-tridecane; [NiCl2(PMe3)2] in tetrahydrofuran
T=65°C; 20 h; Further stages.;
参考文献
Penney, Jonathan M.; Miller, Joseph A.
Tetrahedron Letters, 2004 , vol. 45, # 25 p. 4989 - 4992
Moulton, Benjamin E.; Whitwood, Adrian C.; Duhme-Klair, Anne K.; Lynam, Jason M.; Fairlamb, Ian J. S.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5320 - 5334
