反应条件
1: 1.) LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, from -78 deg C to RT
2: 1.) (R)-binaphthol, B(OMe)3, 4 Angstroem molecular sieves / 1.) CH2Cl2, toluene, 0 deg C, 10 min, 2.) CH2Cl2, toluene, -78 deg C, 20 h
3: 83 percent / H2 / 10percent Pd/C / methanol / 14 h / 760 Torr / Ambient temperature
View Scheme
参考文献
Ishihara, Kazuaki; Miyata, Mayumi; Hattoi, Kouji; Tada, Toshiji; Yamamoto, Hisashi
Journal of the American Chemical Society, 1994 , vol. 116, # 23 p. 10520 - 10524
