5-(3-氟苯基)呋喃-2-羧酸合成路线 （共 5 条）
反应条件
water; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct T=200°C; 0.0333333 h; Microwave irradiation;
参考文献
IRM LLC
Patent: WO2005/39496 A2, 2005 ;
Location in patent: Page/Page column 59 ;
WO 2005/039496 A2
反应条件
lithium hydroxide hydrate in tetrahydrofuran; methanol; water 24 h; Inert atmosphere;
参考文献
Ballard, T. Eric; Wang, Xia; Olekhnovich, Igor; Koerner, Taylor; Seymour, Craig; Salamoun, Joseph; Warthan, Michelle; Hoffman, Paul S.; Macdonald, Timothy L.
ChemMedChem, 2011 , vol. 6, # 2 p. 362 - 377
反应条件
1: Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane / 100 °C 2: aq. LiOH / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 12 p. 3258 - 3261
反应条件
1: Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane / 100 °C 2: aq. LiOH / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 12 p. 3258 - 3261
反应条件
1: 3-fluorophenylamine With hydrogenchloride; sodium nitrite 2: furan-2-carboxylic acid With copper dichloride in water; acetone Meerwein arylation;
参考文献
Chemical Biology and Drug Design, , vol. 79, # 1 p. 121 - 127
