5-[3-(三氟甲基)苯基]-2-糠酸合成路线 （共 7 条）
反应条件
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene in water; tert-butyl alcohol T=20°C; 11 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 21 p. 6384 - 6393,10
反应条件
potassium hydroxide in ethanol 0.5 h; Reflux;
参考文献
Russian Journal of Organic Chemistry, , vol. 45, # 4 p. 541 - 550
反应条件
hydrogenchloride; copper dichloride; sodium nitrite in acetone
参考文献
Journal of Pharmaceutical Sciences, , vol. 69, # 1 p. 107 - 110
反应条件
1.1: sodium nitrite; hydrogenchloride / water / 0.33 h / 0 - 110 °C 1.2: 0.25 h / 0 °C 1.3: 14 h / 0 - 20 °C 2.1: sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium chlorite / water; tert-butyl alcohol / 11 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 21 p. 6384 - 6393,10
反应条件
1.1: sodium nitrite; hydrogenchloride / water / 0.33 h / 0 - 110 °C 1.2: 0.25 h / 0 °C 1.3: 14 h / 0 - 20 °C 2.1: sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium chlorite / water; tert-butyl alcohol / 11 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 21 p. 6384 - 6393,10
反应条件
1: SOCl2 / DMF / 0.67 h / Heating
2: 88 percent / triethylamine / CHCl3 / 1.) -5 to 0 deg C, 30 min; 2.) r.t., 1 h
3: PCl5 / benzene / 0.25 h / 75 °C
4: sodium azide / dimethylformamide / 0.5 h
5: 92 percent / 1.) 3M KOH, 2.) 15percent HCl / methanol; H2O / 1 h / Heating
View Scheme
参考文献
Janda; Voticky; Svetlik; et al.
Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 6 p. 1505 - 1514
反应条件
thionyl chloride in benzene
Reflux;
参考文献
Gorak; Obushak; Matiichuk; Lytvyn
Russian Journal of Organic Chemistry, 2009 , vol. 45, # 4 p. 541 - 550
