JANSSEN PHARMACEUTICA N.V.
Patent: WO2005/51387 A1, 2005 ;
Location in patent: Page/Page column 46; 50 ;
WO 2005/051387 A1
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反应条件
1: 3-bromo-2-triisopropylsilyloxyfuran With n-butyllithium in tetrahydrofuran; hexane T=-78 - -25°C; 2: 1-iodo-butane in tetrahydrofuran; hexane T=-25 - 20°C; 3: With water in tetrahydrofuran; hexane Further stages. Title compound not separated from byproducts.;
参考文献
Boukouvalas, John; Loach, Richard P.
Journal of Organic Chemistry, 2008 , vol. 73, # 20 p. 8109 - 8112
